|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Williams_syndrome
|
|
gptkbp:domain
|
gptkb:LIM_domain
protein kinase domain
PDZ domain
|
|
gptkbp:encodedBy
|
LIMK1 gene
|
|
gptkbp:Entrez_Gene_ID
|
3984
ENSG00000106683
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
|
|
gptkbp:fullName
|
LIM domain kinase 1
|
|
gptkbp:function
|
serine/threonine kinase
regulation of actin cytoskeleton
|
|
gptkbp:gene
|
gptkb:LIMK1
|
|
gptkbp:HGNC_ID
|
6616
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LIMK1
|
|
gptkbp:inhibitedBy
|
BMS-5
LIMKi3
|
|
gptkbp:interactsWith
|
gptkb:PAK1
gptkb:ROCK1
SSH1L
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
cell migration
neuronal development
|
|
gptkbp:locatedOnChromosome
|
7q11.23
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:mutationAssociatedWith
|
cognitive deficits
visuospatial impairment
|
|
gptkbp:OMIM
|
601329
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2V2O
|
|
gptkbp:phosphorylates
|
Ser323
Thr508
cofilin
|
|
gptkbp:regulates
|
gptkb:Rac1
gptkb:Cdc42
gptkb:Rho_GTPases
actin filament dynamics
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P53667
|
|
gptkbp:bfsParent
|
gptkb:PAK1
|
|
gptkbp:bfsLayer
|
7
|