|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:CDC42
gptkb:RAC1
|
|
gptkbp:alternativeName
|
gptkb:PAK1
alpha-PAK
p65-PAK
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:neurofibromatosis_type_2
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:encodedBy
|
gptkb:PAK1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
pancreas
|
|
gptkbp:function
|
cell proliferation
cell survival
cell motility
regulation of cytoskeleton
serine/threonine kinase activity
|
|
gptkbp:gene
|
gptkb:PAK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21-activated kinase 1
|
|
gptkbp:inhibitedBy
|
FRAX597
G-5555
IPA-3
|
|
gptkbp:interactsWith
|
gptkb:PIX
gptkb:GIT1
gptkb:PAK2
gptkb:PAK3
NCK
PAK-interacting exchange factor (PIX)
|
|
gptkbp:involves
|
gptkb:MAPK_signaling_pathway
apoptosis
cell cycle regulation
cancer progression
|
|
gptkbp:locatedOnChromosome
|
11q13.5-q14
|
|
gptkbp:member
|
gptkb:PAK_family
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:OMIM
|
602590
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1F3M
|
|
gptkbp:phosphorylates
|
gptkb:BAD
gptkb:LIMK1
gptkb:MERLIN
|
|
gptkbp:target
|
FRAX597
G-5555
IPA-3
|
|
gptkbp:UniProtID
|
Q13153
|
|
gptkbp:bfsParent
|
gptkb:PAK1
|
|
gptkbp:bfsLayer
|
7
|