|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:CDC42
gptkb:RAC1
|
|
gptkbp:alias
|
PAK-1
STE20 homolog
alpha-PAK
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodevelopmental disorders
|
|
gptkbp:discoveredBy
|
Manser et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
PAK1 protein
|
|
gptkbp:Entrez_Gene_ID
|
5058
ENSG00000149269
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
various tissues
|
|
gptkbp:fullName
|
p21 (RAC1) activated kinase 1
|
|
gptkbp:function
|
cell proliferation
cell survival
cell motility
regulation of cytoskeleton
serine/threonine kinase activity
|
|
gptkbp:HGNC_ID
|
gptkb:PAK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PAK1 gene
|
|
gptkbp:involves
|
gptkb:MAPK_signaling_pathway
cell cycle regulation
|
|
gptkbp:locatedOnChromosome
|
11q13.5-q14
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autism_spectrum_disorder
intellectual disability
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Pak1
|
|
gptkbp:proteinFamily
|
gptkb:PAK_family
serine/threonine kinase domain
p21-binding domain
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
apoptosis
gene expression
cell cycle progression
neurite outgrowth
actin cytoskeleton
cell adhesion
cell morphology
|
|
gptkbp:target
|
therapeutic research
small molecule inhibitors
|
|
gptkbp:UniProtID
|
Q13153
|
|
gptkbp:bfsParent
|
gptkb:PAK1
|
|
gptkbp:bfsLayer
|
7
|