|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:CDC42
gptkb:RAC1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
PAK2 gene
|
|
gptkbp:Entrez_Gene_ID
|
5062
ENSG00000149269
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.1
|
|
gptkbp:fullName
|
p21-activated kinase 2
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
apoptosis regulation
cell motility
regulation of cytoskeleton
|
|
gptkbp:gene
|
gptkb:PAK2
|
|
gptkbp:GO_term
|
GO:0005524
GO:0004672
GO:0006468
|
|
gptkbp:hasIsoform
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:8590
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PAK2
|
|
gptkbp:inhibitedBy
|
IPA-3
|
|
gptkbp:interactsWith
|
gptkb:PIX
gptkb:CDC42
gptkb:GIT1
gptkb:NCK1
gptkb:RAC1
|
|
gptkbp:locatedOnChromosome
|
gptkb:3q29
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Pak2
rat Pak2
|
|
gptkbp:PDB
|
gptkb:1YHV
2BVA
|
|
gptkbp:phosphorylates
|
gptkb:LIMK1
myosin light chain
|
|
gptkbp:postTranslationalModification
|
phosphorylation
cleavage by caspase-3
|
|
gptkbp:RefSeq
|
NM_002577
|
|
gptkbp:structure
|
contains protein kinase domain
contains p21-Rho-binding domain
|
|
gptkbp:studiedBy
|
apoptosis research
cancer biology
cell signaling studies
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
cytoskeleton
|
|
gptkbp:UniProtID
|
Q13177
|
|
gptkbp:bfsParent
|
gptkb:PAK1
|
|
gptkbp:bfsLayer
|
7
|