|
gptkbp:instanceOf
|
UniProt accession number
|
|
gptkbp:alternativeName
|
gptkb:CYP2C9
Cytochrome P450, family 2, subfamily C, polypeptide 9
CYPIIC9_HUMAN
|
|
gptkbp:associatedWith
|
NSAID metabolism
Phenytoin toxicity
Warfarin sensitivity
|
|
gptkbp:cofactor
|
Heme
|
|
gptkbp:Entrez_Gene_ID
|
1559
ENSP00000260682
|
|
gptkbp:enzymeCommissionNumber
|
EC 1.14.14.20
|
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gptkbp:family
|
gptkb:Cytochrome_P450
|
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gptkbp:function
|
Drug metabolism
Monooxygenase activity
|
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gptkbp:gene
|
gptkb:CYP2C9
|
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gptkbp:hasIsoform
|
CYP2C9.1
CYP2C9.11
CYP2C9.2
CYP2C9.3
CYP2C9.4
CYP2C9.5
CYP2C9.6
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2C9*11
gptkb:CYP2C9*2
gptkb:CYP2C9*3
gptkb:CYP2C9*5
gptkb:CYP2C9*6
|
|
gptkbp:HGNC_ID
|
2593
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P08174
|
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gptkbp:inducedBy
|
gptkb:Phenobarbital
gptkb:Carbamazepine
gptkb:Phenytoin
gptkb:Dexamethasone
gptkb:Rifampicin
|
|
gptkbp:inhibitedBy
|
gptkb:Fluoxetine
gptkb:Amiodarone
gptkb:Fluconazole
Cimetidine
Miconazole
Sulfaphenazole
Ticlopidine
|
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gptkbp:last_modified
|
2024-01-17
|
|
gptkbp:last_sequence_update
|
2002-11-01
|
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gptkbp:length
|
490 amino acids
|
|
gptkbp:locatedOnChromosome
|
Chromosome 10q23.33
|
|
gptkbp:molecularWeight
|
55,766 Da
|
|
gptkbp:OMIM
|
601130
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
Drug metabolism - cytochrome P450
Metabolism of xenobiotics by cytochrome P450
|
|
gptkbp:PDB
|
1OG5
1R90
1R9O
1OG2
|
|
gptkbp:protein_name
|
Cytochrome P450 2C9
|
|
gptkbp:refersTo
|
Human protein: Cytochrome P450 2C9
|
|
gptkbp:RefSeq
|
NP_000762.2
|
|
gptkbp:reviewedBy
|
Yes
|
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gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:sequenceVersion
|
2
|
|
gptkbp:subcellularLocation
|
gptkb:Endoplasmic_reticulum
|
|
gptkbp:subfamily
|
2C
|
|
gptkbp:substrate
|
gptkb:S-warfarin
gptkb:Phenytoin
gptkb:Warfarin
gptkb:Celecoxib
gptkb:Diclofenac
gptkb:Losartan
gptkb:Ibuprofen
Flurbiprofen
Glyburide
Tolbutamide
|
|
gptkbp:tissue_specificity
|
Liver
Kidney
Small intestine
|
|
gptkbp:UniProt_release
|
2024_02
|
|
gptkbp:UniProtKB_entry
|
gptkb:P08174
|
|
gptkbp:bfsParent
|
gptkb:CD55
|
|
gptkbp:bfsLayer
|
7
|