|
gptkbp:instanceOf
|
gptkb:drug
anticonvulsant
|
|
gptkbp:approvedBy
|
gptkb:FDA
1953
|
|
gptkbp:ATCCode
|
gptkb:N03AB02
|
|
gptkbp:bioavailability
|
70-100%
|
|
gptkbp:brand
|
gptkb:Epanutin
gptkb:Dilantin
|
|
gptkbp:CASNumber
|
57-41-0
|
|
gptkbp:contraindication
|
heart block
hypersensitivity to phenytoin
sinus bradycardia
|
|
gptkbp:discoveredBy
|
gptkb:Heinrich_Biltz
|
|
gptkbp:discoveredIn
|
1908
|
|
gptkbp:drugClass
|
gptkb:hydantoin
|
|
gptkbp:drugInteraction
|
gptkb:isoniazid
gptkb:warfarin
gptkb:valproic_acid
gptkb:carbamazepine
cimetidine
oral contraceptives
|
|
gptkbp:eliminationHalfLife
|
22 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:firstMarketedBy
|
gptkb:Parke-Davis
|
|
gptkbp:firstSynthesized
|
gptkb:Heinrich_Biltz
|
|
gptkbp:hasMolecularFormula
|
C15H12N2O2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Phenytoin
|
|
gptkbp:KEGGID
|
D08445
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
blocks voltage-gated sodium channels
|
|
gptkbp:meltingPoint
|
295°C
|
|
gptkbp:MeSH_ID
|
D010673
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:proteinBinding
|
90%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL521
1707
1775
DB00252
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nystagmus
rash
drowsiness
ataxia
gingival hyperplasia
megaloblastic anemia
|
|
gptkbp:synonym
|
gptkb:diphenylhydantoin
|
|
gptkbp:UNII
|
6158TKW0C5
|
|
gptkbp:usedFor
|
epilepsy
seizure prevention
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Anticonvulsants
|
|
gptkbp:bfsLayer
|
7
|