Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
nonsteroidal anti-inflammatory drug
|
| gptkbp:ATCCode |
gptkb:M01AB05
|
| gptkbp:brand |
gptkb:Voltaren
gptkb:Cataflam gptkb:Zipsor gptkb:Zorvolex |
| gptkbp:CASNumber |
15307-86-5
|
| gptkbp:chemicalFormula |
C14H11Cl2NO2
|
| gptkbp:contraindication |
peptic ulcer
third trimester of pregnancy hypersensitivity to NSAIDs severe heart failure |
| gptkbp:discoveredBy |
gptkb:Ciba-Geigy
|
| gptkbp:discoveredIn |
1973
|
| gptkbp:eliminationHalfLife |
1-2 hours
|
| gptkbp:excretion |
urine
bile |
| https://www.w3.org/2000/01/rdf-schema#label |
Diclofenac
|
| gptkbp:interactsWith |
gptkb:SSRIs
gptkb:methotrexate lithium corticosteroids ACE inhibitors diuretics anticoagulants other NSAIDs |
| gptkbp:IUPACName |
2-[2-(2,6-dichloroanilino)phenyl]acetic acid
|
| gptkbp:legalStatus |
prescription only (most countries)
|
| gptkbp:mechanismOfAction |
COX inhibitor
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
296.1 g/mol
|
| gptkbp:pregnancyCategory |
D (US, third trimester)
C (US, first and second trimester) |
| gptkbp:proteinBinding |
>99%
|
| gptkbp:riskFactor |
gastrointestinal bleeding
renal impairment cardiovascular events |
| gptkbp:routeOfAdministration |
oral
topical intramuscular rectal ophthalmic |
| gptkbp:sideEffect |
nausea
dizziness headache rash elevated liver enzymes gastrointestinal upset |
| gptkbp:usedFor |
pain relief
inflammation reduction treatment of arthritis |
| gptkbp:WHO_Essential_Medicines_List |
yes
|
| gptkbp:bfsParent |
gptkb:Zentiva
|
| gptkbp:bfsLayer |
7
|