|
gptkbp:instanceOf
|
gptkb:nonsteroidal_anti-inflammatory_drug
|
|
gptkbp:ATCCode
|
gptkb:M01AB05
|
|
gptkbp:brand
|
gptkb:Voltaren
gptkb:Cataflam
gptkb:Zipsor
gptkb:Zorvolex
|
|
gptkbp:CASNumber
|
15307-86-5
|
|
gptkbp:chemicalFormula
|
C14H11Cl2NO2
|
|
gptkbp:contraindication
|
gptkb:peptic_ulcer
third trimester of pregnancy
hypersensitivity to NSAIDs
severe heart failure
|
|
gptkbp:discoveredBy
|
gptkb:Ciba-Geigy
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:eliminationHalfLife
|
1-2 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:interactsWith
|
gptkb:SSRIs
gptkb:methotrexate
lithium
corticosteroids
ACE inhibitors
diuretics
anticoagulants
other NSAIDs
|
|
gptkbp:IUPACName
|
2-[2-(2,6-dichloroanilino)phenyl]acetic acid
|
|
gptkbp:legalStatus
|
prescription only (most countries)
|
|
gptkbp:mechanismOfAction
|
COX inhibitor
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
296.1 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US, third trimester)
C (US, first and second trimester)
|
|
gptkbp:proteinBinding
|
>99%
|
|
gptkbp:riskFactor
|
gastrointestinal bleeding
renal impairment
cardiovascular events
|
|
gptkbp:routeOfAdministration
|
oral
topical
intramuscular
rectal
ophthalmic
|
|
gptkbp:sideEffect
|
nausea
dizziness
headache
rash
elevated liver enzymes
gastrointestinal upset
|
|
gptkbp:usedFor
|
pain relief
inflammation reduction
treatment of arthritis
|
|
gptkbp:WHO_Essential_Medicines_List
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Diclofenac
|