|
gptkbp:instanceOf
|
gptkb:drug
anticonvulsant
mood stabilizer
|
|
gptkbp:approvedInUS
|
1968
|
|
gptkbp:ATCCode
|
gptkb:N03AF01
|
|
gptkbp:bioavailability
|
70–85%
|
|
gptkbp:brand
|
gptkb:Tegretol
gptkb:Carbatrol
gptkb:Epitol
gptkb:Equetro
|
|
gptkbp:CASNumber
|
298-46-4
|
|
gptkbp:chemicalClass
|
gptkb:dibenzazepine
|
|
gptkbp:contraindication
|
history of bone marrow depression
hypersensitivity to tricyclic compounds
|
|
gptkbp:discoveredBy
|
gptkb:Walter_Schindler
|
|
gptkbp:discoveredIn
|
1953
|
|
gptkbp:drugInteraction
|
gptkb:phenytoin
gptkb:warfarin
gptkb:erythromycin
oral contraceptives
|
|
gptkbp:eliminationHalfLife
|
12–17 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasInChIKey
|
VZCYOOQTPOCHFL-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C15H12N2O
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Carbamazepine
|
|
gptkbp:KEGGID
|
D00294
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
voltage-gated sodium channel blocker
|
|
gptkbp:meltingPoint
|
189°C
|
|
gptkbp:MeSH_ID
|
D002220
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:proteinBinding
|
70–80%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL108
2457
2554
DB00564
|
|
gptkbp:routeOfAdministration
|
oral
rectal
|
|
gptkbp:seriousAdverseEffect
|
gptkb:Stevens-Johnson_syndrome
aplastic anemia
agranulocytosis
|
|
gptkbp:sideEffect
|
nausea
vomiting
dizziness
rash
drowsiness
hyponatremia
|
|
gptkbp:solubility
|
poor
|
|
gptkbp:UNII
|
33CM23913M
|
|
gptkbp:usedFor
|
gptkb:trigeminal_neuralgia
bipolar disorder
epilepsy
peripheral neuropathy
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Anticonvulsants
|
|
gptkbp:bfsLayer
|
7
|