|
gptkbp:instanceOf
|
gptkb:drug
nonsteroidal anti-inflammatory drug
|
|
gptkbp:approvalYear
|
1998
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:M01AH01
|
|
gptkbp:brand
|
gptkb:Pfizer
gptkb:Celebrex
Onsenal
|
|
gptkbp:CASNumber
|
gptkb:169590-42-5
|
|
gptkbp:category
|
gptkb:NSAID
COX-2 selective inhibitor
|
|
gptkbp:chemicalClass
|
diaryl-substituted pyrazole
|
|
gptkbp:contraindication
|
history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
hypersensitivity to sulfonamides
|
|
gptkbp:developedBy
|
gptkb:G.D._Searle_&_Company
|
|
gptkbp:eliminationHalfLife
|
11 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
C17H14F3N3O2S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Celecoxib
|
|
gptkbp:interactsWith
|
gptkb:warfarin
gptkb:fluconazole
gptkb:aspirin
lithium
ACE inhibitors
diuretics
|
|
gptkbp:KEGGID
|
D00217
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
nonsteroidal anti-inflammatory drug
|
|
gptkbp:MedlinePlusID
|
a699022
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:patentExpired
|
2014 (US)
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
97%
|
|
gptkbp:PubChem_CID
|
2662
CHEMBL685
DB00482
|
|
gptkbp:riskFactor
|
may cause gastrointestinal bleeding
may increase risk of heart attack or stroke
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
edema
headache
hypertension
gastrointestinal upset
increased risk of cardiovascular events
|
|
gptkbp:synonym
|
SC-58635
|
|
gptkbp:UNII
|
J2M7L3IAPZ
|
|
gptkbp:usedFor
|
osteoarthritis
pain relief
rheumatoid arthritis
acute pain
ankylosing spondylitis
primary dysmenorrhea
|
|
gptkbp:bfsParent
|
gptkb:P35367
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|