|
gptkbp:instanceOf
|
gptkb:drug
angiotensin II receptor blocker
|
|
gptkbp:approvalYear
|
1995
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
C09CA01
|
|
gptkbp:bioavailability
|
33%
|
|
gptkbp:brand
|
gptkb:Cozaar
|
|
gptkbp:CASNumber
|
114798-26-4
|
|
gptkbp:category
|
gptkb:sartan
antihypertensive agent
|
|
gptkbp:contraindication
|
pregnancy
hypersensitivity
|
|
gptkbp:developedBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:discoveredBy
|
gptkb:DuPont
|
|
gptkbp:eliminationHalfLife
|
2 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:firstBook
|
yes
|
|
gptkbp:form
|
gptkb:tablet
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:hasMolecularFormula
|
C22H23ClN6O
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Losartan
|
|
gptkbp:interactsWith
|
gptkb:NSAIDs
lithium
diuretics
potassium supplements
other antihypertensives
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
gptkb:angiotensin_II_receptor_antagonist
|
|
gptkbp:metabolism
|
liver
EXP3174
|
|
gptkbp:molecularWeight
|
422.91 g/mol
|
|
gptkbp:patentExpired
|
2010
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:prescribes
|
adults
children over 6 years
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:riskFactor
|
hypotension
renal impairment
angioedema
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
dizziness
fatigue
cough
hyperkalemia
|
|
gptkbp:usedFor
|
heart failure
hypertension
diabetic nephropathy
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|