|
gptkbp:instanceOf
|
gptkb:drug
gptkb:anticoagulant
|
|
gptkbp:administeredBy
|
gptkb:tablet
oral suspension
|
|
gptkbp:antidote
|
gptkb:vitamin_A
fresh frozen plasma
prothrombin complex concentrate
|
|
gptkbp:approvedBy
|
1954
|
|
gptkbp:ATCCode
|
gptkb:B01AA03
|
|
gptkbp:brand
|
gptkb:Coumadin
gptkb:Jantoven
gptkb:Marevan
|
|
gptkbp:CASNumber
|
gptkb:81-81-2
|
|
gptkbp:category
|
coumarin derivative
|
|
gptkbp:chemicalFormula
|
C19H16O4
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
pregnancy
uncontrolled hypertension
active bleeding
|
|
gptkbp:discoveredBy
|
gptkb:Karl_Paul_Link
|
|
gptkbp:discoveredIn
|
1948
|
|
gptkbp:eliminationHalfLife
|
20-60 hours
|
|
gptkbp:foundIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Warfarin
|
|
gptkbp:interactsWith
|
gptkb:phenytoin
gptkb:NSAIDs
gptkb:aspirin
gptkb:carbamazepine
antibiotics
barbiturates
green leafy vegetables
amiodarone
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
vitamin K antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:monitors
|
gptkb:INR_(International_Normalized_Ratio)
|
|
gptkbp:pregnancyCategory
|
X (contraindicated)
|
|
gptkbp:proteinBinding
|
99%
|
|
gptkbp:purpose
|
rodenticide
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
bleeding
bruising
purple toe syndrome
skin necrosis
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:usedFor
|
prevention of blood clots
prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
prevention of stroke in people with mechanical heart valves
|
|
gptkbp:bfsParent
|
gptkb:81-81-2
|
|
gptkbp:bfsLayer
|
6
|