|
gptkbp:instanceOf
|
antifungal medication
triazole antifungal
|
|
gptkbp:approvalYear
|
1990
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:J02AC01
|
|
gptkbp:brand
|
gptkb:Canesten_Oral
gptkb:Diflucan
gptkb:Trican
|
|
gptkbp:CASNumber
|
gptkb:86386-73-4
|
|
gptkbp:chemicalFormula
|
C13H12F2N6O
|
|
gptkbp:contraindication
|
hypersensitivity to fluconazole
concomitant use with certain drugs (e.g., terfenadine, cisapride)
|
|
gptkbp:discoveredBy
|
gptkb:Pfizer
|
|
gptkbp:drugClass
|
antifungal
|
|
gptkbp:eliminationHalfLife
|
20-50 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fluconazole
|
|
gptkbp:interactsWith
|
gptkb:cyclosporine
gptkb:phenytoin
gptkb:rifampin
gptkb:theophylline
gptkb:warfarin
gptkb:benzodiazepines
gptkb:erythromycin
statins
oral hypoglycemics
|
|
gptkbp:isOnWHOList
|
yes
|
|
gptkbp:IUPACName
|
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
|
|
gptkbp:lactationSafety
|
generally considered safe
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
inhibits fungal cytochrome P450 enzyme 14α-demethylase
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
306.27 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US)
C (single, low dose)
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
headache
rash
elevated liver enzymes
|
|
gptkbp:synonym
|
gptkb:Diflucan
UK-49,858
|
|
gptkbp:usedFor
|
prevention of fungal infections in immunocompromised patients
treatment of candidiasis
treatment of cryptococcal meningitis
treatment of fungal infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|