|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:OCT4
gptkb:POU_domain,_class_5,_transcription_factor_1
|
|
gptkbp:associatedWith
|
induced pluripotent stem cells
cellular reprogramming
|
|
gptkbp:biologicalProcess
|
transcriptional activation
protein-protein interaction
DNA binding
|
|
gptkbp:conservedIn
|
mammals
|
|
gptkbp:discoveredBy
|
gptkb:Hans_R._Schöler
|
|
gptkbp:domain
|
homeobox domain
POU domain
|
|
gptkbp:encodes
|
gptkb:OCT4_protein
gptkb:POU_domain,_class_5,_transcription_factor_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000204531
5460
|
|
gptkbp:expressedIn
|
gptkb:germ_cells
embryonic stem cells
|
|
gptkbp:function
|
stem cell maintenance
transcriptional regulation
regulation of pluripotency
|
|
gptkbp:HGNC_ID
|
9211
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
POU5F1 gene
|
|
gptkbp:interactsWith
|
gptkb:KLF4_protein
gptkb:NANOG_protein
gptkb:SOX2_protein
gptkb:c-MYC_protein
|
|
gptkbp:involvedIn
|
germ cell development
early embryonic development
|
|
gptkbp:length
|
360 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
6p21.33
|
|
gptkbp:marking
|
pluripotency
embryonic stem cells
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
infertility
|
|
gptkbp:OMIM
|
164177
|
|
gptkbp:orthologInMouse
|
Pou5f1
|
|
gptkbp:regulates
|
gptkb:POU_family
gptkb:SOX2_gene
gptkb:NANOG_gene
self-renewal pathways
|
|
gptkbp:regulatoryElement
|
enhancer region
promoter region
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
epigenetic regulation
microRNAs
|
|
gptkbp:UniProtID
|
gptkb:Q01860
|
|
gptkbp:usedIn
|
gptkb:Yamanaka_factors
stem cell research
cellular reprogramming protocols
|
|
gptkbp:YamanakaFactor
|
true
|
|
gptkbp:bfsParent
|
gptkb:Oct3/4
|
|
gptkbp:bfsLayer
|
6
|