neurotrophic receptor tyrosine kinase 1

URI: https://gptkb.org/entity/neurotrophic_receptor_tyrosine_kinase_1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alsoKnownAs gptkb:TrkA
gptkb:NTRK1
gptkbp:discoveredBy Lamballe et al.
gptkbp:discoveredIn 1991
gptkbp:domain transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:encodedBy gptkb:NTRK1_gene
gptkbp:Entrez_Gene_ID 4914
ENSG00000198400
gptkbp:expressedIn gptkb:nervous_system
gptkbp:function tyrosine kinase activity
receptor for nerve growth factor (NGF)
gptkbp:HGNC_ID 8031
https://www.w3.org/2000/01/rdf-schema#label neurotrophic receptor tyrosine kinase 1
gptkbp:involvedIn neuronal differentiation
neuronal survival
gptkbp:ligand gptkb:nerve_growth_factor_(NGF)
gptkbp:locatedOnChromosome chromosome 1
gptkbp:memberOf neurotrophic tyrosine receptor kinase family
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:congenital_insensitivity_to_pain_with_anhidrosis
gptkbp:OMIM 191315
gptkbp:orthologInMouse gptkb:Ntrk1
gptkbp:target gptkb:entrectinib
gptkb:larotrectinib
gptkbp:UniProtID gptkb:P04629
gptkbp:bfsParent gptkb:NTRK1
gptkb:NTRK1_gene
gptkb:HGNC:8007
gptkbp:bfsLayer 7