|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD54
|
|
gptkbp:biologicalProcess
|
immune response
cell-cell adhesion
integrin binding
leukocyte migration
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:ICAM1_gene
|
|
gptkbp:expressedIn
|
endothelial cells
immune cells
epithelial cells
|
|
gptkbp:fullName
|
gptkb:Intercellular_Adhesion_Molecule_1
|
|
gptkbp:function
|
immune response
cell adhesion
leukocyte endothelial transmigration
|
|
gptkbp:gene
|
gptkb:ICAM1
|
|
gptkbp:hasBiomarker
|
gptkb:cardiovascular_disease
multiple sclerosis
inflammation
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5344
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ICAM-1
|
|
gptkbp:involvedIn
|
atherosclerosis
autoimmune diseases
inflammation
cancer metastasis
rhinovirus infection
|
|
gptkbp:ligand
|
gptkb:LFA-1
gptkb:Mac-1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:molecularWeight
|
85-110 kDa
|
|
gptkbp:OMIM
|
147840
|
|
gptkbp:PDB
|
gptkb:1IC1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:receptorFor
|
rhinovirus
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
type I transmembrane glycoprotein
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
gptkb:P05362
|
|
gptkbp:upregulatedBy
|
gptkb:IL-1
gptkb:TNF-alpha
gptkb:IFN-gamma
cytokines
|
|
gptkbp:bfsParent
|
gptkb:CR3_domain
gptkb:PfEMP1
|
|
gptkbp:bfsLayer
|
6
|