|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CD106
INCAM-110
vascular cell adhesion protein 1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
asthma
multiple sclerosis
rheumatoid arthritis
|
|
gptkbp:binds
|
integrin alpha4beta1 (VLA-4)
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
VCAM1 gene
|
|
gptkbp:Entrez_Gene_ID
|
7412
|
|
gptkbp:expressedIn
|
endothelial cells
inflammatory response
|
|
gptkbp:foundIn
|
vascular endothelium
|
|
gptkbp:fullName
|
Vascular cell adhesion molecule 1
|
|
gptkbp:function
|
cell adhesion
leukocyte-endothelial cell signal transduction
|
|
gptkbp:gene
|
VCAM1
|
|
gptkbp:GO_term
|
GO:0005886 (plasma membrane)
GO:0007155 (cell adhesion)
GO:0005515 (protein binding)
|
|
gptkbp:HGNC_ID
|
12663
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VCAM-1
|
|
gptkbp:inducedBy
|
gptkb:tumor_necrosis_factor_alpha
gptkb:interleukin-1
cytokines
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
|
|
gptkbp:medicalUse
|
biomarker for inflammation
target for anti-inflammatory drugs
|
|
gptkbp:molecularWeight
|
~81-110 kDa
|
|
gptkbp:OMIM
|
192225
|
|
gptkbp:orthologInMouse
|
Vcam1
|
|
gptkbp:PDB
|
1VSC
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:regulates
|
upregulated by inflammatory cytokines
downregulated after inflammation resolution
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:role
|
atherosclerosis
inflammation
immune response
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
P19320
|
|
gptkbp:bfsParent
|
gptkb:alpha-4_beta-1_integrin
|
|
gptkbp:bfsLayer
|
7
|