|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:92_kDa_type_IV_collagenase
gptkb:gelatinase_B
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
arthritis
chronic obstructive pulmonary disease
|
|
gptkbp:cofactor
|
zinc
calcium
|
|
gptkbp:discoveredBy
|
gptkb:G._Murphy
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:Entrez_Gene_ID
|
4318
|
|
gptkbp:enzymeClassification
|
EC 3.4.24.35
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
fibroblasts
neutrophils
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_9
|
|
gptkbp:function
|
degrades extracellular matrix proteins
|
|
gptkbp:gene
|
gptkb:MMP9
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_001005366
NM_004994
|
|
gptkbp:HGNC_ID
|
HGNC:7158
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP9
|
|
gptkbp:inhibitedBy
|
gptkb:TIMP1
gptkb:TIMP2
|
|
gptkbp:locatedOnChromosome
|
20q13.12
|
|
gptkbp:location
|
extracellular space
secreted
|
|
gptkbp:molecularWeight
|
92 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mmp9
|
|
gptkbp:pathway
|
cell migration
inflammatory response
extracellular matrix organization
|
|
gptkbp:PDB
|
1L6J
4H3X
|
|
gptkbp:regulates
|
regulated by growth factors
induced by cytokines
|
|
gptkbp:relatedTo
|
angiogenesis
inflammation
tissue remodeling
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:collagen_type_IV
gelatin
|
|
gptkbp:UniProtID
|
P14780
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|