|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:H-2_class_I_(in_mice)
gptkb:HLA_class_I_(in_humans)
|
|
gptkbp:antigenProcessing
|
gptkb:proteasome
|
|
gptkbp:antigenSource
|
endogenous proteins
|
|
gptkbp:antigenTransport
|
gptkb:TAP_transporter
|
|
gptkbp:associatedWith
|
autoimmune diseases
viral immunity
|
|
gptkbp:binds
|
peptides
|
|
gptkbp:component
|
gptkb:adaptive_immune_system
cell-mediated immunity
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Dausset
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
gptkb:major_histocompatibility_complex
|
|
gptkbp:expressedIn
|
cell surface
|
|
gptkbp:foundIn
|
all nucleated cells
|
|
gptkbp:function
|
antigen presentation
|
|
gptkbp:gene
|
gptkb:HLA-A
gptkb:HLA-B
gptkb:HLA-C
|
|
gptkbp:hasPolymorphism
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC class I
|
|
gptkbp:involvedIn
|
gptkb:graft-versus-host_disease
immune surveillance
viral infection response
tumor immunity
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6_(human)
gptkb:chromosome_17_(mouse)
|
|
gptkbp:mouseGene
|
gptkb:H-2D
gptkb:H-2K
gptkb:H-2L
|
|
gptkbp:notExpressedOn
|
red blood cells
|
|
gptkbp:peptideLength
|
8-10 amino acids
|
|
gptkbp:presentedBy
|
cytotoxic T lymphocytes
|
|
gptkbp:presentIn
|
vertebrates
|
|
gptkbp:recognizedBy
|
gptkb:CD8+_T_cells
|
|
gptkbp:role
|
immune response
transplant rejection
self/non-self discrimination
|
|
gptkbp:significance
|
organ transplantation
immunotherapy
disease susceptibility
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
other mammals
|
|
gptkbp:structure
|
gptkb:beta-2_microglobulin
alpha chain
heterodimer
|
|
gptkbp:bfsParent
|
gptkb:MHC_molecule
|
|
gptkbp:bfsLayer
|
6
|