|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
Cyclooxygenase-2
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
rheumatoid arthritis
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:EC_number
|
1.14.99.1
|
|
gptkbp:encodedBy
|
gptkb:PTGS2_gene
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
|
|
gptkbp:function
|
catalyzes conversion of arachidonic acid to prostaglandins
|
|
gptkbp:GOID
|
GO:0004620
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
COX-2
|
|
gptkbp:inhibitedBy
|
gptkb:NSAIDs
gptkb:etoricoxib
gptkb:rofecoxib
gptkb:celecoxib
|
|
gptkbp:involvedIn
|
fever
pain
inflammation
|
|
gptkbp:locatedOnChromosome
|
chromosome 1q31.1 (human)
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
nuclear envelope
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:OMIM
|
600262
|
|
gptkbp:PDB
|
5IKQ
|
|
gptkbp:relatedTo
|
gptkb:COX-1
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
P35354
|
|
gptkbp:upregulatedBy
|
cytokines
growth factors
tumor promoters
|
|
gptkbp:bfsParent
|
gptkb:NM_002524
gptkb:P35367
gptkb:PTGS2
gptkb:COX
gptkb:AP1
gptkb:Prostaglandin_G/H_synthase_2
gptkb:CHEMBL29
|
|
gptkbp:bfsLayer
|
7
|