Statements (727)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:disease
gptkb:virus gptkb:character |
| gptkbp:acute_infection_rate |
15-45% of cases
|
| gptkbp:affects |
gptkb:Pigs
gptkb:animals gptkb:birds gptkb:humans |
| gptkbp:allows |
pre-boot applications
|
| gptkbp:appears_in |
gptkb:3_Idiots
|
| gptkbp:associated_with |
gptkb:hepatocellular_carcinoma
public awareness campaigns liver failure emergency preparedness liver disease global health security high mortality rates severe symptoms vaccine development efforts endemic regions clinical trials for treatments zoonotic transmission extrahepatic manifestations HIV co-infection increases severity Hemorrhagic fever CDC guidelines for management WHO response initiatives biological research risks community outbreaks healthcare worker infections international collaboration for research international travel risks |
| gptkbp:associated_with_outbreaks |
gptkb:Lassa_fever
Junin virus infection Machupo virus infection |
| gptkbp:belongs_to |
family Iflaviridae
|
| gptkbp:body_shape |
Spherical
|
| gptkbp:can_be_configured_for |
Setup Utility
|
| gptkbp:cause |
gptkb:virus
gptkb:Influenza gptkb:poliomyelitis Hand, foot, and mouth disease dengue fever avian influenza Hepatitis C infection disease in insects Arenavirus disease Arenaviral disease |
| gptkbp:caused_by |
gptkb:hepatitis_B_virus
viruses HCV (Hepatitis C virus) |
| gptkbp:character_traits |
gptkb:DENV-1
gptkb:DENV-2 gptkb:DENV-3 gptkb:DENV-4 three |
| gptkbp:chronic_infection_management |
requires lifelong care
|
| gptkbp:chronic_infection_prevalence |
5% to 10% in adults
90% in infants |
| gptkbp:chronic_infection_rate |
70-85% of cases
|
| gptkbp:chronic_management |
requires regular medical follow-up
|
| gptkbp:climate_impact |
influenced by temperature
influenced by rainfall patterns |
| gptkbp:clinical_trial |
new antiviral agents
combination therapies long-term follow-up studies Mild to moderate illness treatment for resistant strains High morbidity in infants Low mortality rate Potential for severe disease Severe neurological complications |
| gptkbp:clinical_use |
Symptomatic treatment
Monitoring for complications |
| gptkbp:co-infection_risk |
gptkb:virus
gptkb:HIV |
| gptkbp:collaboration |
World Health Organization efforts
elimination targets by 2030 |
| gptkbp:communication_system |
Direct contact
Aerosol droplets Bite from infected rodent Direct contact with infected fluids Inhalation of aerosolized particles |
| gptkbp:community_health |
gptkb:quarantine_measures
yes public awareness campaigns awareness campaigns surveillance vaccination campaigns outbreak management screening recommendations requires surveillance can lead to liver cancer can lead to liver cirrhosis culling of infected birds significant in many countries significant global health issue major concern in many countries requires education on prevention requires rapid response Outbreaks in schools Surveillance required |
| gptkbp:community_impact |
endemic in some regions
outbreaks reported affects quality of life annual epidemics potential pandemics can lead to discrimination |
| gptkbp:complication |
gptkb:hepatocellular_carcinoma
liver failure liver cancer liver cirrhosis portal hypertension chronic liver disease |
| gptkbp:complications |
gptkb:pneumonia
respiratory failure muscle atrophy liver cancer bronchitis sinus infections cirrhosis scoliosis joint deformities post-polio syndrome worsening of chronic conditions |
| gptkbp:condition |
Meningitis
Encephalitis Myocarditis Respiratory illness |
| gptkbp:controls |
public awareness campaigns
vaccination of poultry monitoring of wild birds |
| gptkbp:cure_rate |
over 95% with modern treatments
|
| gptkbp:death |
varies
varies by serotype varies by virus type higher in severe cases around 15% for Lassa fever up to 90% for Ebola |
| gptkbp:depicted_in |
Traditionalist
|
| gptkbp:developed_by |
gptkb:Intel
Industry Collaboration |
| gptkbp:diagnosis |
PCR
blood test serological tests Serological tests serology Serological testing PCR test PCR tests WHO guidelines PCR testing viral culture HCV RNA test HCV antibody test rapid tests Virus isolation |
| gptkbp:discovered_by |
gptkb:1989
gptkb:Venezuela gptkb:Michael_Houghton in 1989 |
| gptkbp:discovery |
1960s
By studying rodent populations advancements in antiviral therapies increased awareness of blood safety led to improved screening methods reduced transmission rates in healthcare settings |
| gptkbp:discovery_year |
1909
|
| gptkbp:diseases |
gptkb:H5_N6
gptkb:H5_N1 gptkb:H7_N9 hepatitis seasonal outbreaks common in urban areas Coxsackievirus Echovirus can lead to liver cancer can lead to liver cirrhosis extrahepatic manifestations liver fibrosis may be asymptomatic may be asymptomatic for years can be asymptomatic for years may resolve spontaneously in some cases can lead to serious health issues can resolve spontaneously Chapare virus outbreaks Guanarito virus outbreaks Junin virus outbreaks Lassa fever outbreaks Machupo virus outbreaks Sabia virus outbreaks Tacaribe virus outbreaks Whitewater Arroyo virus outbreaks occur in Africa occur in Asia occur in South America linked to vaccine-derived strains |
| gptkbp:distribution |
Worldwide presence
|
| gptkbp:duration |
8 to 12 weeks
typically 8 to 12 weeks long-term for chronic cases |
| gptkbp:economic_impact |
trade restrictions
poultry industry loss of livestock |
| gptkbp:enables |
hardware initialization
secure boot |
| gptkbp:endemic_to |
gptkb:South_America
Central Africa West Africa |
| gptkbp:epidemiology |
global prevalence
Seasonal outbreaks Common in children |
| gptkbp:eradication_status |
near eradication
|
| gptkbp:family |
gptkb:Arenaviridae
gptkb:Orthomyxoviridae gptkb:Flaviviridae gptkb:Picornaviridae |
| gptkbp:famous_quote |
All is well
|
| gptkbp:financial_support |
available through various organizations
|
| gptkbp:first_isolation |
1928
|
| gptkbp:flight_style |
Lipid bilayer
|
| gptkbp:genetic_reassortment |
occurs
|
| gptkbp:genetic_studies |
high
|
| gptkbp:genotype |
genotype 1 is the most common
six main genotypes |
| gptkbp:genotypes |
six genotypes
|
| gptkbp:genus |
gptkb:virus
gptkb:Flavivirus gptkb:Hepacivirus gptkb:Influenzavirus_A |
| gptkbp:geographic_distribution |
Worldwide
worldwide tropical regions subtropical regions |
| gptkbp:global_burden |
millions of cases annually
|
| gptkbp:has_conflict_with |
gptkb:students
gptkb:neighborhood |
| gptkbp:has_impact_on |
Student Life
|
| gptkbp:has_influence_on |
Students' Careers
|
| gptkbp:has_type |
gptkb:H1_N1
gptkb:H3_N2 gptkb:H5_N1 gptkb:H7_N9 |
| gptkbp:hemagglutinin |
surface protein
|
| gptkbp:historical_impact |
major epidemics in the 20th century
significant public health campaigns |
| gptkbp:hosts |
gptkb:Primates
gptkb:humans Rats Mice Guinea pigs |
| https://www.w3.org/2000/01/rdf-schema#label |
virus
|
| gptkbp:impact_on_pregnancy |
breastfeeding is generally safe
can be transmitted from mother to child most infants are not infected |
| gptkbp:included |
WHO list of priority diseases
|
| gptkbp:includes |
gptkb:Lassa_fever
gptkb:Crimean-Congo_hemorrhagic_fever gptkb:Marburg_virus_disease Ebola virus disease |
| gptkbp:incubation_period |
4 to 10 days
30 to 180 days |
| gptkbp:infection |
can lead to dengue hemorrhagic fever
can lead to dengue shock syndrome |
| gptkbp:infection_route |
Inhalation
Ingestion |
| gptkbp:is_a |
gptkb:antagonist
gptkb:cultural_icon Complex Character Mentor Figure Character with Flaws Key Character Symbol of Tradition Character with Complexity Character with Depth Character with Vision Character with Influence Character with Challenges Character with Development Character with Goals Character with Legacy Character with Relationships Character with Growth Representation of Authority Cautionary Figure Character with Ambition Character with Impact Character with Influence on Others Character with Motivations Memorable Villain Character with Conflicts Character with Arc Character with Authority Character with Legacy in Education Character with Lessons Educational Figure Film's Antagonist Symbol of Rigid Education |
| gptkbp:is_adopted_by |
PC Manufacturers
|
| gptkbp:is_affected_by |
gptkb:children
|
| gptkbp:is_associated_with |
gptkb:Public_School
Pandemics Seasonal outbreaks Global health concerns High mortality rates in certain strains |
| gptkbp:is_challenged_by |
Innovative Ideas
Student Rebellion |
| gptkbp:is_characterized_by |
Hemagglutinin
Neuraminidase Ambisense RNA genome |
| gptkbp:is_compared_to |
Rancho's Philosophy
|
| gptkbp:is_compatible_with |
gptkb:Linux
gptkb:mac_OS gptkb:Windows Virtual Machines UEFI Shell |
| gptkbp:is_criticized_for |
gptkb:neighborhood
|
| gptkbp:is_critiqued_by |
Lack of Creativity
|
| gptkbp:is_designed_for |
gptkb:x86_architecture
gptkb:ARM_architecture High-Performance Computing |
| gptkbp:is_enhanced_by |
Secure Boot Technology
|
| gptkbp:is_implemented_in |
gptkb:virus
|
| gptkbp:is_influenced_by |
gptkb:Cultural_Norms
|
| gptkbp:is_involved_in |
Examinations
Student Evaluations |
| gptkbp:is_known_for |
High Expectations
Antigenic drift Zoonotic potential Antigenic shift Strict Disciplinary Measures |
| gptkbp:is_known_to |
Cause severe illness in vulnerable populations
Mutate rapidly Require annual vaccine updates |
| gptkbp:is_linked_to |
Zoonotic transmission
Viral reassortment High mortality rates in endemic regions Severe disease in pregnant women |
| gptkbp:is_managed_by |
Firmware Management
|
| gptkbp:is_monitored_by |
gptkb:Centers_for_Disease_Control_and_Prevention
gptkb:World_Health_Organization genomic sequencing Global health organizations liver function tests environmental sampling clinical monitoring viral load tests liver imaging acute flaccid paralysis monitoring |
| gptkbp:is_motivated_by |
Academic Excellence
|
| gptkbp:is_opposed_by |
Unconventional Thinking
|
| gptkbp:is_part_of |
gptkb:architecture
gptkb:Orthomyxoviridae gptkb:Cultural_Commentary Boot Process System Startup System Firmware Climactic Moments Viral pathogens Respiratory viruses Viral hemorrhagic fevers Influenza virus classification Film's Central Conflict |
| gptkbp:is_recognized_as |
gptkb:1967
gptkb:1989 1950s 1970s insects in the 1960s |
| gptkbp:is_related_to |
Other RNA viruses
|
| gptkbp:is_represented_in |
Authority Figure
|
| gptkbp:is_respected_by |
gptkb:faculty
|
| gptkbp:is_standardized_by |
gptkb:UEFI_Forum
UEFI Specification 2.9 |
| gptkbp:is_studied_for |
Vaccine development
Therapeutic interventions |
| gptkbp:is_studied_in |
gptkb:Public_health
Epidemiology Virology Infectious disease research Vaccine efficacy studies Viral pathogenesis research Biosafety laboratories |
| gptkbp:is_supported_by |
Operating Systems
Security Features Motherboard Manufacturers |
| gptkbp:is_taught_in |
Engineering
|
| gptkbp:is_used_for |
system recovery
Firmware Updates Hardware Abstraction System Integrity system configuration |
| gptkbp:is_used_in |
gptkb:Embedded_Systems
gptkb:Personal_Computers Servers Io T Devices |
| gptkbp:is_vaccinated_against |
Influenza vaccine
|
| gptkbp:is_visible_from |
gptkb:Flashbacks
|
| gptkbp:is_vulnerable_to |
gptkb:Albert_Bruce_Sabin
gptkb:inactivated_polio_vaccine gptkb:hepatitis_B_vaccine gptkb:Jonas_Salk gptkb:Dengvaxia available no vaccine available logistical issues vaccine hesitancy inactivated vaccines live attenuated vaccines long-lasting immunity no effective vaccine available oral polio vaccine recombinant vaccines high efficacy high in developed countries access in remote areas low in some developing countries No specific vaccine available |
| gptkbp:issues |
Public health authorities
|
| gptkbp:larval_stage |
gptkb:horse_race
gptkb:birds gptkb:humans pigs |
| gptkbp:liver_biopsy |
used to assess liver damage
|
| gptkbp:liver_transplant |
may be necessary in severe cases
possible for severe cases |
| gptkbp:mechanism_of_action |
occurs
|
| gptkbp:neuraminidase |
surface protein
|
| gptkbp:notable_species |
gptkb:Lassa_virus
gptkb:Iflavirus_A gptkb:Iflavirus_B gptkb:Iflavirus_C gptkb:Arenavirus_2 gptkb:Chapare_virus gptkb:Guanarito_virus gptkb:Junin_virus gptkb:Machupo_virus gptkb:Sabia_virus gptkb:Tacaribe_virus gptkb:Whitewater_Arroyo_virus poultry wild birds domestic birds Arenavirus 1 |
| gptkbp:nutritional_value |
Single-stranded RNA
Non-enveloped |
| gptkbp:occurs_in |
varies
|
| gptkbp:pandemic_potential |
high
moderate |
| gptkbp:personality_trait |
Intelligent
Strict |
| gptkbp:portrayed_by |
gptkb:Boman_Irani
|
| gptkbp:prevalence |
approximately 71 million people infected
approximately 71 million people infected worldwide approximately 257 million people infected |
| gptkbp:prevention |
Vaccination
vaccination biosecurity measures mask wearing safe sex practices use of personal protective equipment Hand hygiene hand hygiene mosquito control Rodent control screening blood products avoidance of mosquito bites avoid sharing needles screening blood donations Avoiding contact with rodents avoidance of contact with infected individuals Vaccination (for some species) Avoiding close contact |
| gptkbp:propagation_method |
blood-to-blood contact
horizontal transmission |
| gptkbp:provides |
gptkb:user_interface
system diagnostics device drivers boot management platform initialization |
| gptkbp:provides_guidance_on |
varies by country
|
| gptkbp:public_awareness |
increased in recent years
aim to reduce stigma Information on symptoms Education on hygiene practices |
| gptkbp:public_health_strategy |
awareness campaigns
vaccination programs screening initiatives |
| gptkbp:relationship_with |
gptkb:Farhan
gptkb:neighborhood gptkb:Raju |
| gptkbp:released_in |
gptkb:2005
|
| gptkbp:replaces |
gptkb:BIOS
|
| gptkbp:replication_site |
Cytoplasm
|
| gptkbp:reprints |
Cytoplasm
|
| gptkbp:research |
Vaccine development
genetic studies Therapeutic interventions Public health measures Epidemiological studies Viral genetics Viral evolution genetic diversity studies Vaccine development efforts vector control strategies long-term effects studies ongoing for vaccines Pathogenesis studies ongoing vaccine development ongoing for antiviral treatments Host interactions treatment resistance studies Ongoing for vaccine development Ongoing studies on treatment |
| gptkbp:research_focus |
gptkb:immunotherapy
Vaccine development genetic diversity genetic studies vaccine development pathogenicity Pathogenesis treatment options treatment optimization improving diagnostics Viral evolution viral evolution pathogenesis transmission dynamics developing a vaccine antiviral resistance Host interactions improving treatment regimens new antiviral therapies understanding viral genetics |
| gptkbp:research_importance |
entomology
|
| gptkbp:reservoir |
gptkb:birds
pigs |
| gptkbp:responds_to |
gptkb:WHO_Global_Hepatitis_Strategy
|
| gptkbp:risk_factor |
healthcare settings
Poor sanitation immunocompromised individuals children and elderly travel to endemic areas multiple sexual partners unprotected sex poor sanitation Young age intravenous drug use previous dengue infection Occupational exposure Crowded living conditions Travel to endemic areas blood transfusions before 1992 healthcare exposure sharing personal items like razors close contact with infected birds poor hygiene practices travel to affected areas sharing personal items Immunocompromised status Exposure to rodents contact with wildlife |
| gptkbp:risk_management |
elderly
pregnant women young children immunocompromised individuals |
| gptkbp:role |
College Dean
|
| gptkbp:scientific_classification |
Lineages
Subtypes major global health issue Biosafety Level 4 pathogen Negative-sense RNA viruses |
| gptkbp:scientific_instruments |
Detection of viral RNA
Isolation in cell culture |
| gptkbp:screenings |
pregnant women
high-risk populations people with liver disease recommended for high-risk populations for high-risk populations |
| gptkbp:seasonal_activities |
more common in winter
More common in summer and fall |
| gptkbp:seed_dispersal |
RNA virus
Single-stranded RNA single-stranded RNA |
| gptkbp:serotype1 |
Mahoney strain
|
| gptkbp:serotype2 |
Lansing strain
|
| gptkbp:serotype3 |
Leon strain
|
| gptkbp:setting |
gptkb:college
|
| gptkbp:side_effect |
gptkb:anemia
fatigue nausea headaches |
| gptkbp:size |
80-130 nm
|
| gptkbp:species |
gptkb:Lassa_virus
gptkb:Guanarito_virus gptkb:Junin_virus gptkb:Machupo_virus gptkb:Sabia_virus |
| gptkbp:specification |
gptkb:UEFI_Specification
|
| gptkbp:structure |
Enveloped virus
|
| gptkbp:supports |
64-bit processing
networking capabilities multiple boot options fast boot modular drivers |
| gptkbp:symptoms |
gptkb:Fever
gptkb:Cough gptkb:pneumonia Fatigue Headache fatigue headache muscle pain nausea Rash abdominal pain cough fever jaundice sore throat vomiting diarrhea rash bleeding Chills muscle weakness Muscle pain Sore throat Hemorrhage paralysis Mouth sores acute respiratory distress syndrome muscle aches high fever loss of appetite joint and muscle pain mild bleeding pain behind the eyes severe respiratory illness Muscle aches 2 to 7 days severe headache Hemorrhagic fever Runny or stuffy nose |
| gptkbp:transmission |
gptkb:blood
gptkb:Aedes_mosquitoes sexual contact Fecal-oral route fecal-oral route airborne droplets mother to child blood-to-blood contact bird to bird bird to human human to human Rodent excreta direct contact with infected bodily fluids Respiratory route |
| gptkbp:treatment |
gptkb:baloxavir_marboxil
gptkb:Ribavirin gptkb:oseltamivir gptkb:zanamivir gptkb:glecaprevir gptkb:ledipasvir gptkb:pibrentasvir gptkb:sofosbuvir gptkb:velpatasvir Supportive care hydration Hydration Rest supportive care varies by individual Monoclonal antibodies Antiviral medications access to care Pain relievers rehabilitation strategies antiviral medications Antiviral therapy antiviral drugs Antipyretics cost of medications stigma associated with infection reduce viral load over 95% with direct-acting antivirals prevent liver damage reduce transmission risk immune therapies |
| gptkbp:treatment_adherence |
important for effectiveness
|
| gptkbp:treatment_cost |
can be very high
|
| gptkbp:treatment_timing |
early treatment recommended
|
| gptkbp:type |
RNA virus
non-enveloped |
| gptkbp:type_of |
gptkb:H1_N1
gptkb:H3_N2 gptkb:H5_N1 gptkb:H7_N9 Coxsackievirus H5 H7 H9 1a 1b 2a Echovirus 6a Enterovirus A Enterovirus B Enterovirus D68 3a 4a 5a |
| gptkbp:vector |
gptkb:Aedes_aegypti
gptkb:Aedes_albopictus gptkb:mammals environmental management biological control methods insecticide use not transmitted by insects |
| gptkbp:whostatus |
public health emergency
|
| gptkbp:wildlife |
high
|
| gptkbp:written_in |
gptkb:C_programming_language
|
| gptkbp:bfsParent |
gptkb:military_unit
gptkb:Liza_Minnelli |
| gptkbp:bfsLayer |
3
|