|
gptkbp:instanceOf
|
gptkb:genus
gptkb:protein
gptkb:virus
cytokine
Biological agent
|
|
gptkbp:abbreviation
|
gptkb:AAV
|
|
gptkbp:activatedBy
|
gptkb:gp130_receptor
|
|
gptkbp:affects
|
gptkb:nervous_system
gastrointestinal tract
respiratory system
|
|
gptkbp:alternativeName
|
gptkb:EBV
gptkb:human_herpesvirus_4
pathogen
Enterovirus
Epstein–Barr_virus
Virus
adeno-associated_virus
adenovirus
bacteriophage
computer_virus
fictional_virus
herpesvirus
inactivated_virus
retrovirus
viral_disease
viral_genome
viral_infection
viral_interleukin-6
viral_protein
viral_vector
virus_family
virus_group
virus_order
virus_serotype
virus_strain
virus_subtype
|
|
gptkbp:antiviralTreatment
|
gptkb:famciclovir
gptkb:valacyclovir
gptkb:acyclovir
gptkb:ganciclovir
|
|
gptkbp:application
|
gene editing
CRISPR delivery
treatment of genetic diseases
gene replacement therapy
|
|
gptkbp:associatedWith
|
gptkb:Kaposi's_sarcoma
gptkb:multicentric_Castleman's_disease
gptkb:primary_effusion_lymphoma
multiple sclerosis
autoimmune diseases
chronic fatigue syndrome
|
|
gptkbp:Baltimore_classification
|
Group I (dsDNA viruses)
Group IV (+)ssRNA viruses
|
|
gptkbp:canBe
|
gptkb:Mutation
gptkb:Baltimore_classification
gptkb:ICTV_classification
Vaccine development
Phage therapy
Pathogenic
Gene therapy
Non-pathogenic
Reassortment
Recombination
|
|
gptkbp:canBeInactivatedBy
|
gptkb:Heat
UV light
Disinfectants
|
|
gptkbp:capsid_symmetry
|
icosahedral
|
|
gptkbp:capsidDiameter
|
100-200 nm
|
|
gptkbp:cause
|
gptkb:Burkitt_lymphoma
gptkb:nasopharyngeal_carcinoma
gptkb:oral_hairy_leukoplakia
gptkb:disease
gptkb:Kaposi's_sarcoma
gptkb:infectious_mononucleosis
gptkb:cytomegalovirus_infection
gptkb:chickenpox
shingles
Hodgkin lymphoma
gastric cancer
herpes simplex
|
|
gptkbp:causesDisease
|
gptkb:hand,_foot,_and_mouth_disease
gptkb:herpangina
myocarditis
encephalitis
poliomyelitis
viral meningitis
|
|
gptkbp:contains
|
Genetic material
|
|
gptkbp:discoveredBy
|
gptkb:Martinus_Beijerinck
gptkb:Karl_Landsteiner
gptkb:Michael_Anthony_Epstein
gptkb:Yvonne_Barr
gptkb:Dmitri_Ivanovsky
1965
1900s
Bob Atchison
M. David Hoggan
|
|
gptkbp:discoveredIn
|
1909
1964
|
|
gptkbp:encodedBy
|
K2 gene
|
|
gptkbp:enveloped
|
true
|
|
gptkbp:envelopeGlycoproteins
|
present
|
|
gptkbp:example
|
gptkb:Influenza_virus
gptkb:COVID-19
gptkb:Herpes_simplex_virus
gptkb:Poliovirus
gptkb:Rabies_virus
gptkb:HIV
gptkb:Ebola_virus
Bacteriophage
|
|
gptkbp:excludes
|
Metabolism
Cellular structure
|
|
gptkbp:family
|
gptkb:Parvoviridae
gptkb:Picornaviridae
gptkb:Herpesviridae
|
|
gptkbp:firstDescribed
|
1892
|
|
gptkbp:firstIsolatedFrom
|
gptkb:Burkitt_lymphoma_cell_line
|
|
gptkbp:foundIn
|
gptkb:human_herpesvirus_8
|
|
gptkbp:geneticMaterialType
|
gptkb:gene
|
|
gptkbp:genomeSense
|
positive-sense
|
|
gptkbp:genomeSize
|
~172 kilobase pairs
120-240 kbp
|
|
gptkbp:genomeType
|
single-stranded DNA
single-stranded RNA
double-stranded DNA
|
|
gptkbp:genus
|
gptkb:Lymphocryptovirus
gptkb:Dependoparvovirus
|
|
gptkbp:hasReplica
|
requires co-infection with helper virus
|
|
gptkbp:hasVaccine
|
no licensed vaccine
|
|
gptkbp:hostCellType
|
gptkb:B_lymphocytes
epithelial cells
|
|
gptkbp:hostedBy
|
gptkb:human
humans
mammals
other primates
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
virus
|
|
gptkbp:immunogenicity
|
low
|
|
gptkbp:inducedBy
|
cell proliferation
angiogenesis
|
|
gptkbp:infects
|
gptkb:Fungi
gptkb:Plants
gptkb:Bacteria
Animals
animals
humans
Archaea
|
|
gptkbp:integratesWith
|
Host genome
|
|
gptkbp:integration_site
|
AAVS1 on human chromosome 19
|
|
gptkbp:latency
|
true
|
|
gptkbp:latencySite
|
neurons
lymphocytes
|
|
gptkbp:latentIn
|
gptkb:B_cells
|
|
gptkbp:mayInclude
|
gptkb:Envelope
|
|
gptkbp:NCBITaxonomyID
|
10376
|
|
gptkbp:non-pathogenic
|
true
|
|
gptkbp:not_associated_with_disease
|
true
|
|
gptkbp:notableFor
|
gptkb:LMP1
EA (early antigen)
EBNA1
VCA (viral capsid antigen)
|
|
gptkbp:notableSpecies
|
gptkb:Cytomegalovirus
gptkb:Poliovirus
gptkb:Herpes_simplex_virus_1
gptkb:Herpes_simplex_virus_2
gptkb:Human_herpesvirus_6
gptkb:Epstein-Barr_virus
gptkb:Kaposi's_sarcoma-associated_herpesvirus
gptkb:Human_herpesvirus_7
gptkb:Varicella-zoster_virus
gptkb:Coxsackievirus_A
gptkb:Coxsackievirus_B
gptkb:Echovirus
gptkb:Enterovirus_71
gptkb:Enterovirus_D68
|
|
gptkbp:number_of_serotypes
|
at least 12
|
|
gptkbp:numberOfGenes
|
70-200
|
|
gptkbp:numberOfSpecies
|
over 100
|
|
gptkbp:order
|
gptkb:Herpesvirales
gptkb:Picornavirales
|
|
gptkbp:parent
|
gptkb:Lymphocryptovirus
|
|
gptkbp:prevalence
|
over 90% of adults worldwide infected
|
|
gptkbp:prevention
|
gptkb:Vaccination
|
|
gptkbp:range
|
gptkb:broadcaster
|
|
gptkbp:reactivationTrigger
|
stress
immunosuppression
UV light
|
|
gptkbp:relatedTo
|
gptkb:Kaposi's_sarcoma-associated_herpesvirus
gptkb:cytomegalovirus
|
|
gptkbp:replicatesIn
|
Host cell
|
|
gptkbp:replicationSite
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:requires_helper_virus
|
gptkb:virus
|
|
gptkbp:revival
|
true
possible in immunosuppressed individuals
|
|
gptkbp:serologicalTest
|
gptkb:EBV_antibody_panel
gptkb:Monospot_test
|
|
gptkbp:shape
|
icosahedral
|
|
gptkbp:SIM
|
gptkb:human_interleukin-6
|
|
gptkbp:size
|
~20 nm
|
|
gptkbp:species
|
gptkb:Human_herpesvirus_8
|
|
gptkbp:structure
|
Capsid
icosahedral capsid
non-enveloped
enveloped icosahedral nucleocapsid
|
|
gptkbp:studiedBy
|
Electron microscopy
Molecular biology techniques
|
|
gptkbp:studiedIn
|
Virology
|
|
gptkbp:subfamily
|
gptkb:Gammaherpesvirinae
gptkb:Alphaherpesvirinae
gptkb:Betaherpesvirinae
|
|
gptkbp:taxonRank
|
gptkb:species
201901
|
|
gptkbp:transduction_efficiency
|
high in dividing and non-dividing cells
|
|
gptkbp:transmission
|
blood
organ transplantation
direct contact
bodily fluids
saliva
|
|
gptkbp:transmissionRoute
|
respiratory droplets
fecal-oral
|
|
gptkbp:transmittedBy
|
gptkb:Vector
Fomites
Direct contact
Airborne transmission
Body fluids
|
|
gptkbp:treatment
|
antiviral drugs
Antiviral drugs
|
|
gptkbp:UniProtID
|
P03101 (for major capsid protein)
|
|
gptkbp:used_in
|
gene therapy
|
|
gptkbp:usedFor
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:virus
gptkb:X-linked_myotubular_myopathy
gptkb:Leber_congenital_amaurosis
gptkb:beta-thalassemia
gptkb:Duchenne_muscular_dystrophy
gptkb:Huntington's_disease
heart failure
hemophilia
neurological disorders
sickle cell disease
retinitis pigmentosa
glycogen storage disease
retinal diseases
spinal muscular atrophy
cystic fibrosis
metabolic disorders
muscle disorders
lysosomal storage diseases
Usher syndrome
|
|
gptkbp:vaccineAvailable
|
gptkb:Varicella-zoster_virus
Herpes zoster
no vaccine for HSV
|
|
gptkbp:bfsParent
|
gptkb:COVID-19
gptkb:Marek's_disease
gptkb:influenza
|
|
gptkbp:bfsLayer
|
4
|