|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SODM_HUMAN
gptkb:IPO-B
gptkb:MNSOD
gptkb:SODM
|
|
gptkbp:alternativeName
|
gptkb:Manganese_superoxide_dismutase
gptkb:MnSOD
|
|
gptkbp:associatedWith
|
gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
mitochondrial dysfunction
|
|
gptkbp:biologicalProcess
|
aging
apoptotic process
cellular response to reactive oxygen species
response to oxidative stress
|
|
gptkbp:cofactor
|
manganese
|
|
gptkbp:discoveredBy
|
gptkb:Fridovich_and_McCord
|
|
gptkbp:encodes
|
gptkb:superoxide_dismutase_[Mn],_mitochondrial
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000112096
6648
|
|
gptkbp:expressedIn
|
all human tissues
|
|
gptkbp:fullName
|
gptkb:superoxide_dismutase_2,_mitochondrial
|
|
gptkbp:function
|
superoxide dismutase activity
catalyzes the dismutation of superoxide radicals to hydrogen peroxide and oxygen
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
gptkb:NM_000636
gptkb:NM_001024465
gptkb:NM_001322944
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11179
|
|
gptkbp:highestExpression
|
gptkb:kidney
heart
liver
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD2
|
|
gptkbp:length
|
222 amino acids
|
|
gptkbp:locatedOnChromosome
|
6q25.3
|
|
gptkbp:location
|
mitochondrial matrix
mitochondrion
|
|
gptkbp:molecularWeight
|
24 kDa
|
|
gptkbp:mutationAssociatedWith
|
mitochondrial dysfunction
increased oxidative stress
|
|
gptkbp:OMIM
|
147460
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sod2
|
|
gptkbp:PDB
|
gptkb:1QNK
gptkb:1LUV
gptkb:1N0J
|
|
gptkbp:proteinFamily
|
gptkb:iron/manganese_superoxide_dismutase_family
|
|
gptkbp:regulates
|
gptkb:NF-kappaB
gptkb:p53
estrogen
|
|
gptkbp:significance
|
polymorphisms associated with disease susceptibility
|
|
gptkbp:UniProtID
|
P04179
|
|
gptkbp:bfsParent
|
gptkb:SOD
gptkb:hsa:6647
|
|
gptkbp:bfsLayer
|
6
|