Mitogen-activated protein kinase kinase 1

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_kinase_1
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:MEK1
gptkb:MAPKK1
gptkb:PRKMK1
gptkbp:associatedWith gptkb:cancer
gptkb:Noonan_syndrome
gptkbp:biologicalProcess cell differentiation
cell proliferation
signal transduction
protein serine/threonine kinase activity
gptkbp:discoveredBy 1992
gptkbp:EC_number 2.7.12.2
gptkbp:function phosphorylates and activates MAP kinases
involved in MAPK/ERK pathway
gptkbp:gene gptkb:MAP2K1
gptkbp:HGNC_ID 6840
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase kinase 1
gptkbp:inhibitedBy gptkb:Selumetinib
gptkb:Cobimetinib
gptkb:Trametinib
gptkbp:length 393
gptkbp:locatedIn gptkb:human_chromosome_15
gptkbp:molecularWeight 43 kDa
gptkbp:mutationAssociatedWith C121S
K57N
Q56P
gptkbp:OMIM 176872
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Map2k1
gptkbp:pathway gptkb:RAS_signaling_pathway
growth factor signaling
MAPK/ERK cascade
gptkbp:PDB 3EQF
gptkbp:phosphorylates gptkb:MAPK1
gptkb:MAPK3
Ser218
Ser222
gptkbp:RefSeq NM_002755
gptkbp:regulates apoptosis
gene expression
cell cycle
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID Q02750
gptkbp:bfsParent gptkb:MEK1
gptkbp:bfsLayer 6