|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
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gptkb:MAP2K1
gptkb:MEK1
|
|
gptkbp:associatedWith
|
gptkb:Noonan_syndrome
gptkb:RASopathies
|
|
gptkbp:biologicalProcess
|
apoptosis
cell proliferation
differentiation
protein serine/threonine kinase activity
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_kinase_1
|
|
gptkbp:Entrez_Gene_ID
|
5604
ENSG00000169032
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_2.7.12.2
|
|
gptkbp:function
|
phosphorylates and activates MAP kinases (ERK1/2)
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPKK1
|
|
gptkbp:inhibitedBy
|
gptkb:Selumetinib
gptkb:Cobimetinib
gptkb:Trametinib
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:OMIM
|
176872
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Map2k1
|
|
gptkbp:phosphorylates
|
RAF kinases
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q02750
|
|
gptkbp:bfsParent
|
gptkb:MEK1
|
|
gptkbp:bfsLayer
|
6
|