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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alsoKnownAs
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gptkb:MEK1
gptkb:Mitogen-activated_protein_kinase_kinase_1
|
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gptkbp:associatedWith
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gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
|
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gptkbp:biologicalProcess
|
signal transduction
regulation of cell cycle
cellular response to growth factor stimulus
protein kinase activity
|
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gptkbp:cellularComponent
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gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:discoveredBy
|
multiple research groups in the 1990s
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gptkbp:encodes
|
MAP2K1 protein
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gptkbp:Entrez_Gene_ID
|
26395 (mouse)
5604 (human)
ENSG00000169032 (human)
ENSMUSG00000004936 (mouse)
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gptkbp:expressedIn
|
various tissues
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gptkbp:function
|
phosphorylates and activates MAPK/ERK
|
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gptkbp:HGNC_ID
|
6840
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Map2k1
|
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gptkbp:inhibitedBy
|
gptkb:Selumetinib
gptkb:Binimetinib
gptkb:Cobimetinib
gptkb:Trametinib
|
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gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_15_(mouse)
chromosome 15q22.31 (human)
|
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gptkbp:mutationAssociatedWith
|
gain-of-function mutations cause developmental disorders
|
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gptkbp:OMIM
|
176872
|
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gptkbp:orthologIn
|
gptkb:MAP2K1
|
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gptkbp:orthologInMouse
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gptkb:Map2k1
|
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gptkbp:pathway
|
gptkb:Ras-Raf-MEK-ERK_pathway
|
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gptkbp:phosphorylates
|
MAPK1 (ERK2)
MAPK3 (ERK1)
|
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gptkbp:proteinFamily
|
dual specificity protein kinase
|
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gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
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gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
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gptkbp:UniProtID
|
Q02750 (human)
|
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gptkbp:bfsParent
|
gptkb:MAP2K1
gptkb:MAP2K1_gene
gptkb:MAPKK1
gptkb:Mitogen-activated_protein_kinase_kinase_1
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gptkbp:bfsLayer
|
7
|