Selumetinib

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:drug
small molecule
MEK inhibitor
gptkbp:approvedBy gptkb:FDA
gptkb:neurofibromatosis_type_1
2020
gptkbp:ATCCode gptkb:L01EE04
gptkbp:brand gptkb:Koselugo
gptkbp:CASNumber 606143-52-6
gptkbp:clinicalTrialPhase Phase III
gptkbp:contraindication hypersensitivity to selumetinib
gptkbp:developedBy gptkb:AstraZeneca
gptkbp:discoveredBy gptkb:Array_BioPharma
gptkbp:eliminationHalfLife 5.6 hours
gptkbp:excretion urine
feces
gptkbp:hasInChIKey QXJYYZQYKJYFHO-RUZDIDTESA-N
gptkbp:hasMolecularFormula C17H15BrClFN4O3
gptkbp:hasPatent CA2509642C
EP1581982B1
US20100280013A1
WO2004061047A1
gptkbp:hasSMILES COc1cc2c(cc1Cl)nc(nc2Br)N[C@@H](CO)C(=O)N
gptkbp:hasUNII 3W8Q1SJW2W
https://www.w3.org/2000/01/rdf-schema#label Selumetinib
gptkbp:indication pediatric patients with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas
gptkbp:KEGGID D09913
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits MAPK/ERK pathway
gptkbp:metabolism liver
gptkbp:molecularWeight 457.68 g/mol
gptkbp:pregnancyCategory Not recommended
gptkbp:PubChem_CID 10127622
DB11760
8292542
CHEMBL1201196
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
diarrhea
abdominal pain
fatigue
rash
elevated liver enzymes
increased creatine phosphokinase
gptkbp:synonym ARRY-142886
AZD6244
gptkbp:target gptkb:MEK1
gptkb:MEK2
gptkbp:bfsParent gptkb:MAP2K1
gptkb:MEK1/2
gptkb:MAPKK1
gptkb:Mitogen-activated_protein_kinase_kinase_1
gptkb:Mitogen-activated_protein_kinase_kinase_2
gptkbp:bfsLayer 7