Trametinib

URI: https://gptkb.org/entity/Trametinib

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug MEK inhibitor
gptkbp:administeredBy	oral
gptkbp:approvedBy	gptkb:FDA gptkb:EMA
gptkbp:ATCCode	gptkb:L01XE25
gptkbp:brand	gptkb:Mekinist
gptkbp:CASNumber	871700-17-3
gptkbp:chemicalFormula	C26H23FIN5O4
gptkbp:combines	gptkb:dabrafenib
gptkbp:contraindication	pregnancy
gptkbp:developedBy	GlaxoSmithKline
gptkbp:discoveredIn	2010s
gptkbp:halfLife	4.5 days
https://www.w3.org/2000/01/rdf-schema#label	Trametinib
gptkbp:inhibitedBy	gptkb:MAPK/ERK_pathway
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits MEK1 and MEK2
gptkbp:metabolism	non-CYP enzymes
gptkbp:molecularWeight	615.4 g/mol
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	diarrhea fatigue hypertension rash cardiomyopathy
gptkbp:target	gptkb:MEK1 gptkb:MEK2
gptkbp:usedFor	treatment of melanoma treatment of non-small cell lung cancer treatment of anaplastic thyroid cancer
gptkbp:bfsParent	gptkb:MAP2K1 gptkb:MAP2K1_gene gptkb:MEK1/2 gptkb:MAPKK1 gptkb:Mitogen-activated_protein_kinase_kinase_1 gptkb:Mitogen-activated_protein_kinase_kinase_2
gptkbp:bfsLayer	7