Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alsoKnownAs |
gptkb:MAP2K1
gptkb:MEK1 |
| gptkbp:associatedWith |
gptkb:cardiofaciocutaneous_syndrome
gptkb:cancer gptkb:Noonan_syndrome |
| gptkbp:biologicalProcess |
apoptosis
cell proliferation differentiation protein serine/threonine kinase activity |
| gptkbp:encodes |
MAP2K1 protein
|
| gptkbp:Entrez_Gene_ID |
5604
ENSG00000169032 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:function |
protein kinase activity
|
| gptkbp:HGNC_ID |
6840
|
| https://www.w3.org/2000/01/rdf-schema#label |
PRKMK1
|
| gptkbp:inhibitedBy |
gptkb:trametinib
gptkb:cobimetinib gptkb:selumetinib |
| gptkbp:involvedIn |
gptkb:MAPK/ERK_signaling_pathway
|
| gptkbp:locatedOnChromosome |
15q22.31
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
colorectal cancer melanoma |
| gptkbp:OMIM |
176872
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:phosphorylates |
gptkb:MAPK1
gptkb:MAPK3 |
| gptkbp:regulates |
RAF kinases
|
| gptkbp:UniProtID |
Q02750
|
| gptkbp:bfsParent |
gptkb:MAP2K1_gene
gptkb:Mitogen-activated_protein_kinase_kinase_1 |
| gptkbp:bfsLayer |
7
|