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gptkbp:instanceOf
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gptkb:protein
proteoglycan
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gptkbp:alternativeName
|
CSPG1
cartilage-specific proteoglycan core protein
chondroitin sulfate proteoglycan 1
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gptkbp:component
|
extracellular matrix
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gptkbp:contains
|
chondroitin sulfate chains
keratan sulfate chains
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gptkbp:degradedBy
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gptkb:matrix_metalloproteinases
aggrecanase
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gptkbp:discoveredBy
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gptkb:Helen_Muir
|
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gptkbp:encodedBy
|
ACAN gene
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gptkbp:firstDescribed
|
1971
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gptkbp:foundIn
|
collagen
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gptkbp:function
|
provides cartilage with load-bearing properties
|
|
https://www.w3.org/2000/01/rdf-schema#label
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aggrecan
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gptkbp:importantFor
|
cartilage function
cartilage structure
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gptkbp:interactsWith
|
hyaluronic acid
link protein
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gptkbp:location
|
chromosome 15q26.1 (human)
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gptkbp:molecularWeight
|
~250 kDa (core protein)
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gptkbp:mutationAssociatedWith
|
osteoarthritis
skeletal dysplasia
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gptkbp:role
|
shock absorption
joint lubrication
tissue hydration
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gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
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gptkbp:structure
|
globular domains G1, G2, G3
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gptkbp:UniProtID
|
P16112
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gptkbp:bfsParent
|
gptkb:ADAMTS5
gptkb:ECM-receptor_interaction
gptkb:chondroitin_sulfate_proteoglycan
gptkb:MMP2_gene
gptkb:gelatinase_B
gptkb:MMP-9
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gptkbp:bfsLayer
|
8
|