|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
DKFZp686A11164
TIMP-2
CSC-21K
Tissue inhibitor of metalloproteinase 2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
tissue remodeling
|
|
gptkbp:biologicalProcess
|
cell proliferation
angiogenesis
extracellular matrix organization
metalloproteinase inhibitor activity
negative regulation of endopeptidase activity
|
|
gptkbp:discoveredBy
|
gptkb:Stetler-Stevenson_et_al.
|
|
gptkbp:encodes
|
TIMP2 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000110330
7077
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1989
|
|
gptkbp:fullName
|
Tissue Inhibitor of Metalloproteinases 2
|
|
gptkbp:function
|
inhibits matrix metalloproteinases
|
|
gptkbp:gene
|
gptkb:TIMP2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11822
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIMP2 gene
|
|
gptkbp:interactsWith
|
gptkb:MMP14
gptkb:MMP2
gptkb:MMP9
|
|
gptkbp:length
|
220 amino acids
approximately 83 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q25
|
|
gptkbp:mutationAssociatedWith
|
osteoarthritis
fibrosis
tumor progression
|
|
gptkbp:numberOfExons
|
5
|
|
gptkbp:numberOfTranscripts
|
2 major
|
|
gptkbp:OMIM
|
188825
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Timp2
|
|
gptkbp:product
|
contains N-terminal and C-terminal domains
|
|
gptkbp:proteinFamily
|
gptkb:TIMP_family
|
|
gptkbp:regulates
|
angiogenesis
extracellular matrix composition
|
|
gptkbp:significance
|
potential therapeutic target
biomarker for cancer progression
|
|
gptkbp:subcellularLocation
|
extracellular space
|
|
gptkbp:UniProtID
|
P16035
|
|
gptkbp:bfsParent
|
gptkb:TIMP2
|
|
gptkbp:bfsLayer
|
7
|