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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:MMP
|
|
gptkbp:activatedBy
|
proteolytic cleavage
|
|
gptkbp:alternativeName
|
matrixin
|
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gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
arthritis
|
|
gptkbp:cofactor
|
zinc
calcium
|
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gptkbp:discoveredBy
|
1962
|
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gptkbp:EC_number
|
3.4.24.-
|
|
gptkbp:enzymeClassification
|
endopeptidase
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
humans
plants
|
|
gptkbp:function
|
degradation of extracellular matrix
tissue remodeling
regulation of cell behavior
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Matrix metalloproteinase
|
|
gptkbp:inhibitedBy
|
gptkb:TIMP_(tissue_inhibitor_of_metalloproteinases)
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:member
|
gptkb:MMP-13
gptkb:MMP-1
gptkb:MMP-2
gptkb:MMP-3
gptkb:MMP-7
gptkb:MMP-9
|
|
gptkbp:proteinFamily
|
gptkb:MMP_gene_family
|
|
gptkbp:regulates
|
gene expression
histone modification
inhibition by TIMPs
|
|
gptkbp:role
|
wound healing
angiogenesis
inflammation
metastasis
neurodegeneration
embryogenesis
fibrosis
tumor invasion
|
|
gptkbp:structure
|
catalytic domain
hemopexin-like domain
pro-domain
|
|
gptkbp:substrate
|
gptkb:elastin
collagen
gelatin
proteoglycans
|
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gptkbp:bfsParent
|
gptkb:MMP
|
|
gptkbp:bfsLayer
|
6
|