|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:matrilysin
gptkb:matrix_metalloproteinase-7
|
|
gptkbp:associatedWith
|
colorectal cancer
pancreatic cancer
inflammatory diseases
gastric cancer
|
|
gptkbp:biologicalProcess
|
metalloendopeptidase activity
extracellular matrix disassembly
|
|
gptkbp:cellularComponent
|
extracellular region
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:discoveredBy
|
gptkb:G._Murphy_et_al.
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000149968
4316
|
|
gptkbp:enzymeClassification
|
metalloproteinase
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_7
|
|
gptkbp:function
|
degrades components of the extracellular matrix
involved in cancer progression
involved in tissue remodeling
involved in wound healing
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:7176
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP7
|
|
gptkbp:inhibitedBy
|
gptkb:TIMP1
gptkb:TIMP2
gptkb:TIMP3
gptkb:TIMP4
|
|
gptkbp:length
|
267 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q22.2
11
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mmp7
|
|
gptkbp:PDB
|
1MMQ
|
|
gptkbp:proteinFamily
|
gptkb:matrix_metalloproteinase_family
|
|
gptkbp:regulates
|
regulated by hormones
regulated by growth factors
regulated by cytokines
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:casein
gptkb:collagen_IV
gelatin
proteoglycans
|
|
gptkbp:UniProtID
|
gptkb:P09237
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|