|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:MAP2K7
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:component
|
gptkb:cytoplasm
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:MAP2K7_gene
|
|
gptkbp:Entrez_Gene_ID
|
5609
|
|
gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
|
gptkbp:function
|
MAP kinase kinase activity
phosphorylates and activates JNK
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
stress-activated MAPK cascade
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MEK7
|
|
gptkbp:inhibitedBy
|
gptkb:5Z-7-oxozeaenol
gptkb:JNK-IN-8
AS602801
|
|
gptkbp:interactsWith
|
gptkb:MKK4
gptkb:TAK1
gptkb:JIP1
JIP2
JIP3
JIP4
|
|
gptkbp:length
|
419
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19p13.2
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~45 kDa
|
|
gptkbp:numberOfExons
|
13
|
|
gptkbp:OMIM
|
603166
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Map2k7
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
|
|
gptkbp:phosphorylates
|
gptkb:Ser271
gptkb:Thr275
autophosphorylation possible
|
|
gptkbp:regulates
|
activated by phosphorylation
activated by environmental stress
activated by pro-inflammatory cytokines
|
|
gptkbp:structure
|
contains protein kinase domain
|
|
gptkbp:substrate
|
gptkb:JNK1
gptkb:JNK2
gptkb:JNK3
|
|
gptkbp:UniProtID
|
gptkb:O14733
|
|
gptkbp:bfsParent
|
gptkb:MKK7
|
|
gptkbp:bfsLayer
|
7
|