|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MEK2
gptkb:MAP2K2
|
|
gptkbp:associatedWith
|
gptkb:cardiofaciocutaneous_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:biologicalProcess
|
apoptosis
cell proliferation
differentiation
signal transduction
protein serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
MAP kinase research community
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:MAP2K2_gene
|
|
gptkbp:Entrez_Gene_ID
|
5605
|
|
gptkbp:enzymeCommissionNumber
|
2.7.12.2
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase_kinase_2
|
|
gptkbp:function
|
phosphorylates and activates MAP kinases
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MKK2
|
|
gptkbp:inhibitedBy
|
gptkb:U0126
gptkb:PD0325901
gptkb:Trametinib
|
|
gptkbp:interactsWith
|
gptkb:MAPK1
gptkb:MAPK3
gptkb:BRAF
gptkb:RAF1
|
|
gptkbp:length
|
400
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:OMIM
|
601263
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:PDB
|
gptkb:3SLS
|
|
gptkbp:phosphorylates
|
Ser218
Ser222
|
|
gptkbp:RefSeq
|
gptkb:NM_030662
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P36507
|
|
gptkbp:bfsParent
|
gptkb:MAP2K2
gptkb:MKK
|
|
gptkbp:bfsLayer
|
7
|