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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alsoKnownAs
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gptkb:MAP2K1
|
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gptkbp:biologicalProcess
|
apoptosis
cell proliferation
differentiation
signal transduction
protein serine/threonine kinase activity
|
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gptkbp:discoveredBy
|
gptkb:Lewis_T._Williams
|
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gptkbp:discoveredIn
|
1992
|
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gptkbp:encodedBy
|
gptkb:MAP2K1_gene
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gptkbp:enzymeClassification
|
gptkb:EC_2.7.12.2
|
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gptkbp:function
|
phosphorylates and activates MAP kinases
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gptkbp:gene
|
gptkb:MAP2K1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MKK1
|
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gptkbp:inhibitedBy
|
gptkb:Selumetinib
gptkb:Cobimetinib
gptkb:Trametinib
|
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gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
15q22.31
|
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gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:molecularWeight
|
43 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:PDB
|
3EQF
|
|
gptkbp:phosphorylates
|
Ser218
Ser222
Raf kinases
|
|
gptkbp:RefSeq
|
NP_002746.1
|
|
gptkbp:significance
|
mutations associated with cancer
mutations associated with cardio-facio-cutaneous syndrome
|
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gptkbp:substrate
|
gptkb:ERK1
gptkb:ERK2
|
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gptkbp:UniProtID
|
Q02750
|
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gptkbp:bfsParent
|
gptkb:MKK
|
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gptkbp:bfsLayer
|
7
|