Mitogen-activated protein kinase kinase

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_kinase
GPTKB entity
Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:MAP2K
gptkbp:activatedBy gptkb:MAP_kinase_kinase_kinase_(MAP3K)
gptkbp:alternativeName gptkb:MAPKK
gptkb:MEK
dual-specificity protein kinase
gptkbp:biologicalProcess signal transduction
gptkbp:domain protein kinase domain
gptkbp:EC_number 2.7.12.2
gptkbp:function phosphorylates mitogen-activated protein kinases (MAPKs)
gptkbp:gene gptkb:MAP2K1
gptkb:MAP2K3
gptkb:MAP2K6
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:MAP2K2
gptkb:MAP2K5
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase kinase
gptkbp:inhibitedBy gptkb:MEK_inhibitors
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:organism gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:pathway gptkb:MAPK/ERK_pathway
gptkb:MAPK/JNK_pathway
gptkb:MAPK/p38_pathway
gptkbp:phosphorylates threonine residue
tyrosine residue
gptkbp:proteinFamily gptkb:MAP2K_family
gptkbp:relevant_in_disease gptkb:cancer
inflammatory diseases
gptkbp:substrate gptkb:MAPK
gptkbp:bfsParent gptkb:MAPKK
gptkb:MEK_(MAPK/ERK_kinase)
gptkb:MKK
gptkbp:bfsLayer 7