Mitogen-activated protein kinase kinase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:abbreviation	gptkb:MAP2K
gptkbp:activatedBy	gptkb:MAP_kinase_kinase_kinase_(MAP3K)
gptkbp:alternativeName	gptkb:MAPKK gptkb:MEK dual-specificity protein kinase
gptkbp:biologicalProcess	signal transduction
gptkbp:domain	protein kinase domain
gptkbp:EC_number	2.7.12.2
gptkbp:function	phosphorylates mitogen-activated protein kinases (MAPKs)
gptkbp:gene	gptkb:MAP2K1 gptkb:MAP2K3 gptkb:MAP2K6 gptkb:MAP2K4 gptkb:MAP2K7 gptkb:MAP2K2 gptkb:MAP2K5
gptkbp:inhibitedBy	gptkb:MEK_inhibitors
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:organism	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:pathway	gptkb:MAPK/ERK_pathway gptkb:MAPK/JNK_pathway gptkb:MAPK/p38_pathway
gptkbp:phosphorylates	threonine residue tyrosine residue
gptkbp:proteinFamily	gptkb:MAP2K_family
gptkbp:relevant_in_disease	gptkb:cancer inflammatory diseases
gptkbp:substrate	gptkb:MAPK
gptkbp:bfsParent	gptkb:MAPKK gptkb:MEK_(MAPK/ERK_kinase)
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Mitogen-activated protein kinase kinase