E3 ubiquitin-protein ligase Mdm2

URI: https://gptkb.org/entity/E3_ubiquitin-protein_ligase_Mdm2
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:E3_ubiquitin-protein_ligase_Mdm2
gptkb:HDMX
Double minute 2 protein
gptkbp:associatedWith gptkb:cancer
gptkb:rhabdomyosarcoma
liposarcoma
gptkbp:biologicalProcess regulation of cell cycle
ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
gptkbp:discoveredBy gptkb:Arnold_J._Levine
gptkbp:discoveredIn 1992
gptkbp:domain RING finger domain
acidic domain
nuclear export signal
nuclear localization signal
p53-binding domain
gptkbp:Entrez_Gene_ID gptkb:ENSG00000135679
gptkbp:function E3 ubiquitin ligase
negative regulator of p53
gptkbp:gene gptkb:MDM2
gptkbp:geneType protein-coding
gptkbp:hasTranscriptVariant multiple
gptkbp:HGNC_ID gptkb:HGNC:6973
https://www.w3.org/2000/01/rdf-schema#label E3 ubiquitin-protein ligase Mdm2
gptkbp:inhibitedBy gptkb:RG7112
gptkb:Nutlin-3
gptkbp:interactsWith gptkb:ARF
gptkb:Ribosomal_proteins
gptkb:p53
gptkbp:locatedOnChromosome gptkb:12q15
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~55 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Mdm2
gptkbp:PDB 1Z1M
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:proteinFamily gptkb:RING_finger_domain_proteins
gptkbp:regulates p53 stability
p53 transcriptional activity
gptkbp:UniProtID gptkb:Q00987
gptkbp:bfsParent gptkb:MDM2
gptkbp:bfsLayer 6