|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD11a/CD18
gptkb:integrin_alpha-L_beta-2
|
|
gptkbp:associatedWith
|
gptkb:leukocyte_adhesion_deficiency
|
|
gptkbp:binds
|
gptkb:ICAM-1
gptkb:ICAM-2
gptkb:ICAM-3
|
|
gptkbp:component
|
gptkb:CD11a
gptkb:CD18
|
|
gptkbp:discoveredBy
|
gptkb:Tim_Springer
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:B_cells
gptkb:T_cells
monocytes
granulocytes
|
|
gptkbp:foundIn
|
gptkb:leukocytes
|
|
gptkbp:fullName
|
gptkb:Lymphocyte_function-associated_antigen_1
|
|
gptkbp:function
|
immune response
cell adhesion
|
|
gptkbp:geneEncodingCD11a
|
gptkb:ITGAL
|
|
gptkbp:geneEncodingCD18
|
gptkb:ITGB2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LFA-1
|
|
gptkbp:OMIM
|
gptkb:153370_(ITGAL)
gptkb:600065_(ITGB2)
|
|
gptkbp:role
|
gptkb:immunological_synapse
antigen recognition
leukocyte extravasation
|
|
gptkbp:structureType
|
integrin
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
gptkb:P05107_(CD18)
gptkb:P20701_(CD11a)
|
|
gptkbp:bfsParent
|
gptkb:ICAM-1
gptkb:ICAM1
|
|
gptkbp:bfsLayer
|
7
|