LFA-1

URI: https://gptkb.org/entity/LFA-1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:CD11a/CD18 gptkb:integrin_alpha-L_beta-2
gptkbp:associatedWith	gptkb:leukocyte_adhesion_deficiency
gptkbp:binds	gptkb:ICAM-1 gptkb:ICAM-2 gptkb:ICAM-3
gptkbp:component	gptkb:CD11a gptkb:CD18
gptkbp:discoveredBy	gptkb:Tim_Springer
gptkbp:discoveredIn	1980s
gptkbp:expressedIn	gptkb:NK_cells gptkb:B_cells gptkb:T_cells monocytes granulocytes
gptkbp:foundIn	gptkb:leukocytes
gptkbp:fullName	gptkb:Lymphocyte_function-associated_antigen_1
gptkbp:function	gptkb:immune_response cell adhesion
gptkbp:geneEncodingCD11a	gptkb:ITGAL
gptkbp:geneEncodingCD18	gptkb:ITGB2
gptkbp:OMIM	gptkb:153370_(ITGAL) gptkb:600065_(ITGB2)
gptkbp:role	gptkb:immunological_synapse antigen recognition leukocyte extravasation
gptkbp:structureType	gptkb:integrin
gptkbp:target	therapeutic antibodies
gptkbp:UniProtID	gptkb:P05107_(CD18) gptkb:P20701_(CD11a)
gptkbp:bfsParent	gptkb:ICAM-1 gptkb:ICAM1
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	LFA-1