Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:LFA-1
lymphocyte function-associated antigen 1 |
| gptkbp:binds |
gptkb:ICAM-1
gptkb:ICAM-2 gptkb:ICAM-3 |
| gptkbp:cellSurfaceMarker |
gptkb:CD11a/CD18
|
| gptkbp:composedOf |
gptkb:CD11a
gptkb:CD18 |
| gptkbp:deficiencyCauses |
gptkb:leukocyte_adhesion_deficiency_type_1
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:expressedIn |
gptkb:NK_cells
gptkb:B_cells gptkb:T_cells monocytes granulocytes |
| gptkbp:family |
integrin family
|
| gptkbp:foundIn |
gptkb:leukocytes
|
| gptkbp:function |
cell adhesion
leukocyte migration |
| gptkbp:geneEncodingAlphaSubunit |
gptkb:ITGAL
|
| gptkbp:geneEncodingBetaSubunit |
gptkb:ITGB2
|
| https://www.w3.org/2000/01/rdf-schema#label |
integrin alpha-L beta-2
|
| gptkbp:involvedIn |
immune response
T cell activation leukocyte extravasation |
| gptkbp:locale |
gptkb:cell_membrane
|
| gptkbp:molecularWeight |
~180 kDa
|
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
heterodimer
|
| gptkbp:bfsParent |
gptkb:LFA-1
|
| gptkbp:bfsLayer |
8
|