|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD54
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
atherosclerosis
autoimmune diseases
inflammation
|
|
gptkbp:discoveredBy
|
Rothlein et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
immunoglobulin-like domains
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000090339
3383
|
|
gptkbp:expressedIn
|
endothelial cells
immune cells
|
|
gptkbp:fullName
|
gptkb:Intercellular_Adhesion_Molecule_1
|
|
gptkbp:function
|
immune response
cell adhesion
leukocyte endothelial transmigration
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0007155
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5344
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ICAM1
|
|
gptkbp:interactsWith
|
gptkb:LFA-1
gptkb:Mac-1
|
|
gptkbp:length
|
505 amino acids
|
|
gptkbp:locatedOnChromosome
|
19
|
|
gptkbp:location
|
gptkb:19p13.2
|
|
gptkbp:molecularWeight
|
85-110 kDa
|
|
gptkbp:numberOfExons
|
7
|
|
gptkbp:OMIM
|
147840
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Icam1
gptkb:rat_Icam1
|
|
gptkbp:pathway
|
gptkb:leukocyte_transendothelial_migration
cell adhesion molecules pathway
immune system pathway
|
|
gptkbp:PDB
|
gptkb:1IC1
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:regulates
|
induced by IFN-gamma
induced by IL-1
induced by TNF-alpha
upregulated by cytokines
|
|
gptkbp:significance
|
therapeutic target
biomarker for inflammation
|
|
gptkbp:structure
|
type I transmembrane glycoprotein
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
cell surface
|
|
gptkbp:UniProtID
|
gptkb:P05362
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:chromosome_19
|
|
gptkbp:bfsLayer
|
6
|