|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:KRAS
gptkb:Ki-ras
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:alternativeSplicing
|
gptkb:K-Ras4A
gptkb:K-Ras4B
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
K-ras
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:locatedOn
|
gptkb:chromosome_12
|
|
gptkbp:memberOf
|
gptkb:RAS_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
oncogenic
pancreatic cancer
bladder cancer
codon 12
codon 13
codon 61
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
6GJ8
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
cancer therapeutics
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:Kras
gptkb:N-ras
gptkb:c-K-ras
|
|
gptkbp:bfsLayer
|
6
|