|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodedBy
|
gptkb:NRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000213281
4893
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
gptkb:NRAS
|
|
gptkbp:hasRefSeqID
|
gptkb:NM_002524
|
|
gptkbp:HGNC_ID
|
7989
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
N-ras
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:locatedOn
|
chromosome 1
|
|
gptkbp:memberOf
|
gptkb:RAS_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:acute_myeloid_leukemia
colorectal cancer
melanoma
hematologic malignancies
|
|
gptkbp:namedAfter
|
gptkb:neuroblastoma
|
|
gptkbp:OMIM
|
164790
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:3CON
gptkb:5UHV
gptkb:6MBT
gptkb:6MBU
gptkb:6MCE
gptkb:6MCH
gptkb:6MCI
4Q21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:regulates
|
gptkb:RAF/MEK/ERK_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:relatedTo
|
gptkb:H-ras
gptkb:K-ras
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
gptkb:Golgi_apparatus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01111
|
|
gptkbp:bfsParent
|
gptkb:NRAS
|
|
gptkbp:bfsLayer
|
5
|