|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alsoKnownAs
|
gptkb:Ras_superfamily
|
|
gptkbp:composedOf
|
gptkb:MRAS
gptkb:RIT1
gptkb:RRAS
gptkb:RRAS2
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
RERG
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
GTP hydrolysis
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:domain
|
G domain
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS family
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
gptkb:SOS1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
codon 12
codon 13
codon 61
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:Ral_pathway
|
|
gptkbp:studiedIn
|
cell biology
molecular biology
oncology
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:MRAS
gptkb:KRAS_protein
gptkb:N-ras
gptkb:human_KRAS
|
|
gptkbp:bfsLayer
|
6
|