|
gptkbp:instanceOf
|
gptkb:protein
hormone
|
|
gptkbp:alternativeName
|
Somatomedin C
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Laron_syndrome
acromegaly
|
|
gptkbp:binds
|
gptkb:IGF_binding_proteins
|
|
gptkbp:discoveredBy
|
D.R. Rinderknecht
|
|
gptkbp:discoveredIn
|
1978
|
|
gptkbp:Entrez_Gene_ID
|
3479
ENSG00000017427
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:skeletal_muscle
collagen
adipose tissue
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_1
|
|
gptkbp:function
|
mediates effects of growth hormone
regulates cell growth and development
stimulates systemic body growth
|
|
gptkbp:gene
|
gptkb:IGF1
|
|
gptkbp:halfLife
|
12-15 hours
|
|
gptkbp:HGNC_ID
|
5464
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF-I
|
|
gptkbp:locatedOnChromosome
|
chromosome 12q23.2
|
|
gptkbp:medicalUse
|
diagnosis of growth disorders
treatment of growth failure
|
|
gptkbp:MeSH_ID
|
D007333
|
|
gptkbp:OMIM
|
147440
|
|
gptkbp:PDB
|
1IMX
|
|
gptkbp:producedBy
|
liver
peripheral tissues
|
|
gptkbp:recipient
|
gptkb:IGF-1_receptor
|
|
gptkbp:RefSeq
|
NM_000618
|
|
gptkbp:regulates
|
inhibited by chronic disease
inhibited by malnutrition
stimulated by growth hormone
|
|
gptkbp:relatedTo
|
gptkb:IGF-II
gptkb:insulin
|
|
gptkbp:role
|
cell differentiation
cell proliferation
fetal development
metabolism regulation
anabolic processes
apoptosis inhibition
|
|
gptkbp:sequence
|
70 amino acids
|
|
gptkbp:structure
|
single-chain polypeptide
|
|
gptkbp:UniProtID
|
P05019
|
|
gptkbp:bfsParent
|
gptkb:IGF-II
|
|
gptkbp:bfsLayer
|
7
|