|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:activatedBy
|
gptkb:phospholipase_C
|
|
gptkbp:alternativeName
|
gptkb:HRH1
gptkb:histamine_receptor_H1
H1R
|
|
gptkbp:binds
|
gptkb:histamine
|
|
gptkbp:discoveredBy
|
gptkb:James_Black
|
|
gptkbp:discoveredIn
|
1972
|
|
gptkbp:encodedBy
|
gptkb:HRH1_gene
|
|
gptkbp:enemyOf
|
gptkb:olopatadine
gptkb:cetirizine
gptkb:loratadine
gptkb:promethazine
gptkb:desloratadine
gptkb:azelastine
gptkb:levocetirizine
gptkb:fexofenadine
diphenhydramine
chlorpheniramine
2-(3-trifluoromethylphenyl)histamine
clemastine
ebastine
|
|
gptkbp:Entrez_Gene_ID
|
3269
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
liver
endothelial cells
smooth muscle
|
|
gptkbp:family
|
rhodopsin-like GPCR
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
increases vascular permeability
involved in neurotransmission
regulates smooth muscle contraction
mediates allergic response
|
|
gptkbp:HGNC_ID
|
5172
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histamine H1 receptor
|
|
gptkbp:improves
|
intracellular calcium
|
|
gptkbp:length
|
487
|
|
gptkbp:locatedOn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3p25
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:OMIM
|
142704
|
|
gptkbp:PDB
|
3RZE
|
|
gptkbp:RefSeq
|
NM_000861
|
|
gptkbp:type
|
Gq/11 protein
|
|
gptkbp:UniProtID
|
gptkb:P35367
|
|
gptkbp:bfsParent
|
gptkb:CHEMBL1540
|
|
gptkbp:bfsLayer
|
6
|