|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:histamine_receptor_H1
|
|
gptkbp:antagonistDrug
|
gptkb:cetirizine
gptkb:loratadine
diphenhydramine
chlorpheniramine
|
|
gptkbp:associatedWith
|
allergic response
inflammatory response
|
|
gptkbp:biologicalProcess
|
neurotransmission
inflammatory response
G protein-coupled receptor signaling pathway
regulation of vascular permeability
histamine receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gene cloning
|
|
gptkbp:encodes
|
gptkb:Histamine_H1_receptor
|
|
gptkbp:Entrez_Gene_ID
|
3269
ENSG00000196639
|
|
gptkbp:expressedIn
|
brain
endothelial cells
immune cells
smooth muscle
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:function
|
increases vascular permeability
modulates immune response
stimulates sensory nerve endings
mediates histamine-induced smooth muscle contraction
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple splice variants
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HRH1 gene
|
|
gptkbp:ligand
|
gptkb:histamine
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3p25
|
|
gptkbp:mutationAssociatedWith
|
gptkb:atopic_dermatitis
asthma
rheumatoid arthritis
allergic diseases
|
|
gptkbp:OMIM
|
142704
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hrh1
|
|
gptkbp:pathway
|
histamine signaling pathway
inflammatory mediator regulation
|
|
gptkbp:product
|
H1R
|
|
gptkbp:recipient
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:type
|
phospholipase C pathway
|
|
gptkbp:UniProtID
|
gptkb:P35367
|
|
gptkbp:bfsParent
|
gptkb:H1
gptkb:antihistamine
|
|
gptkbp:bfsLayer
|
6
|