|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:COX-2
gptkb:Prostaglandin_G/H_synthase_2
Cyclooxygenase-2
|
|
gptkbp:associatedWith
|
gptkb:cancer
pain
inflammation
|
|
gptkbp:biologicalProcess
|
inflammatory response
prostaglandin biosynthetic process
prostaglandin-endoperoxide synthase activity
|
|
gptkbp:cellularComponent
|
endoplasmic reticulum membrane
nuclear outer membrane
|
|
gptkbp:EC_number
|
1.14.99.1
|
|
gptkbp:encodedBy
|
gptkb:PTGS2
|
|
gptkbp:Entrez_Gene_ID
|
5743
ENSP00000226222
|
|
gptkbp:expressedIn
|
inducible
|
|
gptkbp:function
|
catalyzes the conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:hasIsoform
|
2
|
|
gptkbp:HGNC_ID
|
9605
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P35367
|
|
gptkbp:inhibitedBy
|
gptkb:NSAIDs
gptkb:Aspirin
gptkb:Celecoxib
|
|
gptkbp:length
|
604 amino acids
|
|
gptkbp:locatedOnChromosome
|
1q31.1
|
|
gptkbp:mass
|
69 kDa
|
|
gptkbp:OMIM
|
600262
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
prostaglandin biosynthesis
|
|
gptkbp:PDB
|
5F19
5IKQ
6COX
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NP_000954.1
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
|
|
gptkbp:targetOfDrug
|
gptkb:NSAIDs
COX-2 inhibitors
|
|
gptkbp:tissue_specificity
|
expressed in many tissues, especially in inflamed tissues
|
|
gptkbp:UniProtID
|
gptkb:P35367
|
|
gptkbp:bfsParent
|
gptkb:antihistamine
|
|
gptkbp:bfsLayer
|
6
|