|
gptkbp:instanceOf
|
gptkb:chemical_compound
neurotransmitter
biogenic amine
immune system mediator
|
|
gptkbp:associatedWith
|
asthma
anaphylaxis
allergic rhinitis
urticaria
scombroid poisoning
|
|
gptkbp:boilingPoint
|
209.5 °C
|
|
gptkbp:CASNumber
|
51-45-6
|
|
gptkbp:category
|
endogenous compound
monoamine neurotransmitter
vasoactive amine
|
|
gptkbp:chemicalFormula
|
C5H9N3
|
|
gptkbp:discoveredBy
|
gptkb:W._Vogt
gptkb:Adolf_Windaus
|
|
gptkbp:discoveredIn
|
1910
|
|
gptkbp:effect
|
gastric acid secretion
itching
smooth muscle contraction
increased vascular permeability
vasodilation
|
|
gptkbp:enemyOf
|
antihistamine
|
|
gptkbp:foundIn
|
human body
fermented foods
animal tissues
spoiled fish
|
|
gptkbp:function
|
acts as neurotransmitter in brain
involved in allergic reactions
mediates inflammatory response
regulates gastric acid secretion
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
histamine
|
|
gptkbp:IUPACName
|
2-(1H-imidazol-4-yl)ethanamine
|
|
gptkbp:meltingPoint
|
83.5 °C
|
|
gptkbp:metabolism
|
gptkb:diamine_oxidase
gptkb:histamine-N-methyltransferase
|
|
gptkbp:molecularWeight
|
111.15 g/mol
|
|
gptkbp:predecessor
|
histidine
|
|
gptkbp:producedBy
|
gptkb:basophils
gptkb:mast_cells
|
|
gptkbp:PubChem_CID
|
774
CHEBI:18295
|
|
gptkbp:recipient
|
gptkb:H1_receptor
gptkb:H2_receptor
gptkb:H3_receptor
gptkb:H4_receptor
|
|
gptkbp:solubility
|
soluble in water
|
|
gptkbp:bfsParent
|
gptkb:L-histidine
gptkb:histidine_decarboxylase
gptkb:H1
gptkb:antihistamine
gptkb:carcinoid_tumors
|
|
gptkbp:bfsLayer
|
6
|