Statements (223)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
signal transduction molecule |
| gptkbp:activatedBy |
gptkb:G_protein-coupled_receptor
gptkb:G_protein-coupled_receptor_(GPCR) GTP binding heterotrimeric G proteins |
| gptkbp:alsoKnownAs |
gptkb:GPCR
gptkb:GPCR_family |
| gptkbp:alternativeName |
gptkb:gamma-aminobutyric_acid_receptor
G-protein_coupled_receptor GABA_receptor GTP-binding_protein G_protein G_protein-coupled_receptor_family |
| gptkbp:binds |
gptkb:gamma-aminobutyric_acid
gptkb:guanosine_diphosphate_(GDP) gptkb:guanosine_triphosphate_(GTP) ligands |
| gptkbp:component |
postsynaptic membrane
presynaptic membrane |
| gptkbp:composedOf |
gptkb:G_protein-coupled_receptors
alpha subunit beta subunit gamma subunit |
| gptkbp:contains |
seven transmembrane domains
|
| gptkbp:database |
gptkb:GPCRdb
gptkb:Gene_Ontology gptkb:PDB gptkb:UniProt gptkb:InterPro gptkb:Reactome gptkb:IUPHAR/BPS_Guide_to_Pharmacology gptkb:KEGG gptkb:Pfam |
| gptkbp:discoveredBy |
gptkb:Robert_J._Lefkowitz
gptkb:Martin_Rodbell gptkb:Alfred_G._Gilman studied since 1970s |
| gptkbp:discoveredIn |
1970s
|
| gptkbp:domain |
extracellular domain
intracellular domain transmembrane domain G domain |
| gptkbp:dysregulationAssociatedWith |
gptkb:depression
epilepsy schizophrenia insomnia anxiety disorders |
| gptkbp:encodedBy |
various genes
GPCR genes |
| gptkbp:evolvesFrom |
ancient eukaryotes
|
| gptkbp:example |
gptkb:receptor_tyrosine_kinase
gptkb:EF-Tu gptkb:angiotensin_receptor gptkb:beta-adrenergic_receptor gptkb:glucagon_receptor gptkb:muscarinic_acetylcholine_receptor gptkb:olfactory_receptor gptkb:rhodopsin gptkb:adrenocorticotropic_hormone_receptor gptkb:melanocortin_receptor gptkb:Ras_protein gptkb:Arf_protein gptkb:Dynamin gptkb:Gα_subunit gptkb:Rab_protein gptkb:Ran_protein gptkb:G12/13_protein gptkb:Gi_protein gptkb:Gq_protein gptkb:Gs_protein gptkb:Rho_protein cannabinoid receptor dopamine receptor opioid antihistamine bombesin receptor bradykinin receptor calcitonin receptor chemokine receptor cholecystokinin receptor endothelin receptor follicle-stimulating hormone receptor free fatty acid receptor frizzled receptor galanin receptor gonadotropin-releasing hormone receptor luteinizing hormone receptor melatonin receptor neuropeptide Y receptor neurotensin receptor orphan GPCR parathyroid hormone receptor prostaglandin receptor purinergic receptor somatostatin receptor tachykinin receptor thyrotropin-releasing hormone receptor trace amine-associated receptor vasopressin receptor thyroid-stimulating hormone receptor |
| gptkbp:expressedIn |
neurons
glial cells |
| gptkbp:foundIn |
central nervous system
prokaryotes eukaryotes eukaryotic cells |
| gptkbp:function |
signal transduction
mediates inhibitory neurotransmission binds guanosine triphosphate (GTP) hydrolyzes GTP to GDP transmit signals from outside the cell to inside |
| gptkbp:GO_term |
GO:0004930
GO:0003924 (GTPase activity) GO:0005525 (GTP binding) |
| https://www.w3.org/2000/01/rdf-schema#label |
G protein-coupled receptor
|
| gptkbp:includes |
metabotropic glutamate receptors
rhodopsin-like receptors secretin receptor family |
| gptkbp:inhibitedBy |
GTP hydrolysis
|
| gptkbp:involvedIn |
vesicle trafficking
cell signaling protein synthesis sensory perception cytoskeleton organization immune response neurotransmission regulation of neuronal excitability synaptic inhibition |
| gptkbp:involves |
cell signaling
regulation of ion channels regulation of metabolic enzymes regulation of other proteins regulation of transporters |
| gptkbp:ligand |
ions
light hormones neurotransmitters peptides odorants |
| gptkbp:location |
inner surface of plasma membrane
|
| gptkbp:membraneLocation |
gptkb:cell_membrane
|
| gptkbp:modulatedBy |
zinc
chloride ions second messenger systems |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:disease gptkb:McCune-Albright_syndrome gptkb:Albright_hereditary_osteodystrophy gptkb:whooping_cough cholera cardiovascular diseases neurological disorders metabolic disorders psychiatric disorders can cause cancer (e.g., Ras mutations) congenital disorders |
| gptkbp:Nobel_Prize_in_Physiology_or_Medicine |
1994
|
| gptkbp:NobelPrizeYear |
gptkb:2012_Nobel_Prize_in_Chemistry
|
| gptkbp:numberOfMembers |
over 800 in humans
|
| gptkbp:OMIM |
600151
|
| gptkbp:orthologIn |
C. elegans GPCR
Drosophila GPCR human GPCR mouse GPCR yeast GPCR zebrafish GPCR |
| gptkbp:presentIn |
gptkb:cell_membrane
|
| gptkbp:proteinFamily |
gptkb:Cys-loop_receptor_family
gptkb:G-protein_coupled_receptor_family_(GABA_B) |
| gptkbp:regulates |
gptkb:adenylate_cyclase
gptkb:phospholipase_C gptkb:MAP_kinase_pathway ion channels inactivated by GAPs (GTPase-activating proteins) activated by GEFs (guanine nucleotide exchange factors) cAMP levels calcium signaling phosphodiesterase |
| gptkbp:relatedTo |
gptkb:cAMP_pathway
gptkb:IP3/DAG_pathway visual signaling calcium signaling olfactory signaling second messenger systems |
| gptkbp:role |
molecular switch
signal transduction |
| gptkbp:signalTransductionMechanism |
G protein activation
|
| gptkbp:significance |
drug targets
|
| gptkbp:structure |
heterodimeric (GABA_B)
pentameric (GABA_A) contains conserved G motifs seven transmembrane domains seven alpha-helices |
| gptkbp:subclassOf |
gptkb:G_protein-coupled_receptor
small molecule cell surface receptor heterotrimeric G protein integral membrane protein |
| gptkbp:subfamily |
gptkb:Adhesion_GPCRs
gptkb:Class_A_(Rhodopsin-like) gptkb:Class_C_(Metabotropic_glutamate/pheromone) gptkb:Class_B_(Secretin-like) gptkb:Class_F_(Frizzled/Taste2) Other GPCRs |
| gptkbp:subspecies |
gptkb:secretin_receptor
gptkb:rhodopsin-like_receptor gptkb:GABA_A_receptor gptkb:GABA_B_receptor gptkb:GABA_C_receptor metabotropic glutamate receptor |
| gptkbp:target |
gptkb:beer
gptkb:benzodiazepines barbiturates pharmaceutical drugs general anesthetics neurosteroids many pharmaceuticals |
| gptkbp:type |
small molecule
heterotrimeric G protein |
| gptkbp:UniProt_Keyword |
KW-0297
|
| gptkbp:bfsParent |
gptkb:GBAR
|
| gptkbp:bfsLayer |
4
|