gptkbp:instanceOf
|
gptkb:drug
antihistamine
|
gptkbp:approvedBy
|
1987
|
gptkbp:ATCCode
|
gptkb:R06AE07
|
gptkbp:brand
|
gptkb:Zyrtec
gptkb:Aller-Tec
gptkb:Alleroff
gptkb:Cetirizine_Hydrochloride
gptkb:Reactine
|
gptkbp:CASNumber
|
83881-52-1
|
gptkbp:chemicalFormula
|
C21H25ClN2O3
|
gptkbp:contraindication
|
severe renal impairment
|
gptkbp:developedBy
|
gptkb:Belgium
|
gptkbp:discoveredBy
|
gptkb:UCB_Pharma
|
gptkbp:eliminationHalfLife
|
8.3 hours
|
gptkbp:excretion
|
urine
feces
|
gptkbp:generation
|
second-generation antihistamine
|
https://www.w3.org/2000/01/rdf-schema#label
|
cetirizine
|
gptkbp:interactsWith
|
gptkb:theophylline
gptkb:ritonavir
sedatives
alcohol (may increase drowsiness)
|
gptkbp:isomerOf
|
gptkb:levocetirizine
|
gptkbp:legalStatus
|
OTC (over-the-counter)
|
gptkbp:mechanismOfAction
|
H1 receptor antagonist
|
gptkbp:MeSH_ID
|
gptkb:D020850
|
gptkbp:metabolism
|
minimal
|
gptkbp:molecularWeight
|
388.888 g/mol
|
gptkbp:pregnancyCategory
|
B (US)
|
gptkbp:prescriptionStatus
|
OTC in many countries
|
gptkbp:proteinBinding
|
93%
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1207
gptkb:DB00341
2678
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
gptkbp:sideEffect
|
abdominal pain
dizziness
fatigue
headache
drowsiness
dry mouth
|
gptkbp:UNII
|
YO7261ME24
|
gptkbp:usedFor
|
gptkb:hay_fever
allergic rhinitis
urticaria
allergy symptoms
|
gptkbp:bfsParent
|
gptkb:Zyrtec
|
gptkbp:bfsLayer
|
5
|