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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
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gptkb:HSP90A
gptkb:HSPC1
gptkb:HSP_86
gptkb:HSP_90-alpha
|
|
gptkbp:associatedWith
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gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:component
|
gptkb:nucleus
cytosol
|
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gptkbp:encodes
|
gptkb:Heat_shock_protein_HSP_90-alpha
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000080824
3320
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
protein folding
ATP binding
protein binding
molecular chaperone
stabilization of proteins
response to stress
|
|
gptkbp:GOProcess
|
protein refolding
cellular response to heat
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5253
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSP90AA1
|
|
gptkbp:interactsWith
|
gptkb:HSP70
gptkb:AHA1
gptkb:CDC37
p23
|
|
gptkbp:length
|
732 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14
14q32.31
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:OMIM
|
140571
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hsp90aa1
|
|
gptkbp:product
|
gptkb:HSP90AA1_protein
|
|
gptkbp:regulates
|
induced by heat shock
regulated by HSF1
|
|
gptkbp:significance
|
target for cancer therapy
biomarker for stress response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:HSP90_inhibitors
gptkb:17-AAG
gptkb:geldanamycin
|
|
gptkbp:UniProtID
|
gptkb:P07900
|
|
gptkbp:bfsParent
|
gptkb:HSP90
gptkb:Hsp90
|
|
gptkbp:bfsLayer
|
7
|